A new diterpenoid, 14β-hydroxy-3-oxo-ent-kaur-16-ene (1), and a new nor-lignan, 8S-( - )-8-(4-hydroxy-3-methoxybenzoyl)-dihydrofuran-8(8'H)-one (4), along with five known compounds were isolated from the twigs and leaves of Croton kongensis Gagnep. Their isolations were clarified and structures were elucidated by the extensive spectroscopic analyses, especially 2D NMR experiments.
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http://dx.doi.org/10.1080/14786419.2013.867856 | DOI Listing |
Bioorg Chem
November 2024
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, Republic of China; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong 264117, Republic of China. Electronic address:
Thirty-two diterpenoids including 18 ent-kauranes (1-6, and 12-23), nine 8,9-seco-ent-kauranes (7-8, and 24-30), four ent-abietanes (9-10, and 31-32), and one crotofolane (11) were isolated from the twigs and leaves of Croton kongensis. The structures of previously unreported crokokaugenoids A-H (1-8), crokoabiegenoids A-B (9-10), and crokocrotogenoid A (11) were determined by spectroscopic data analyses, TDDFT-ECD and GIAO NMR calculations, and X-ray crystallographic studies. All compounds were evaluated for their cytotoxic activity against five human tumor cell lines, and the structure-activity relationships were discussed.
View Article and Find Full Text PDFHeliyon
April 2024
Department of Acupuncture, Jurong Hospital Affiliated to Jiangsu University, Jurong, 212400, Jiangsu, China.
The prevalence of obesity and its primary associated comorbidities, such as type 2 diabetes and fatty liver disease, has reached epidemic proportions, with no successful treatment available at present. Heat shock protein 90 (HSP90), a crucial chaperone, plays a key role in lipogenesis (DNL) by stabilizing and maintaining sterol regulatory element binding protein (SREBP) activity. Kongensin A (KA), derived from , inhibits RIP3-mediated necrosis, showing promise as an anti-necrotic and anti-inflammatory agent.
View Article and Find Full Text PDFFitoterapia
January 2023
School of Pharmacy, Lanzhou University, Lanzhou 730000, PR China. Electronic address:
Croton kongensis Gagnepain. belongs to the genus Croton, the Euphorbiaceae family, mainly distributed in Hainan and southern Yunnan, China. The aim of present study was to acquire secondary metabolites of the ethanol extract obtained from the leaves and twigs of C.
View Article and Find Full Text PDFJ Med Chem
July 2021
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P. R. China.
Triple-negative breast cancer (TNBC) is a lethal malignancy without safe and effective therapeutic drugs. In this study, the anti-TNBC bioassay-guided isolation of the medicinal plant followed by the structural modification led to the construction of a small -kaurane diterpenoid library (-). With subsequent biological screening, 20 highly potent compounds (ICs < 3 μM) were identified.
View Article and Find Full Text PDFVirusdisease
December 2021
Faculty of Biology, University of Science, Vietnam National University Hanoi, Hanoi, Vietnam.
Porcine epidemic diarrhea virus (PEDV) causes diarrhea in pigs leading to severe illnesses and high mortality rates. The development of medicinal agents to treat PEDV infection is therefore crucial. In this study, antiviral activities against PEDV of ethanol and aqueous extracts of 17 Vietnamese traditional medicinal plants were evaluated using the cytopathic effect-based assay.
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