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Novel FGF21 analogues through structure-based optimization for therapeutic development.
Acta Biochim Biophys Sin (Shanghai)
December 2024
Frontiers Science Center for Synthetic Biology (Ministry of Education), Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, Tianjin 300072, China.
Fibroblast growth factor 21 (FGF21) plays a pivotal role in regulating metabolic processes and energy homeostasis, making it a promising therapeutic avenue for various obesity-related conditions. However, its therapeutic efficacy faces challenges due to its suboptimal pharmacokinetics and bioactivity. To overcome these limitations, we adapt a strategy in which key amino acid residues responsible for enhanced activity are pinpointed through sequence alignment and comparative analysis to develop long-acting FGF21 analogs.
View Article and Find Full Text PDFOptimizing screening practice for gestational diabetes mellitus in primary healthcare facilities in Tanzania: research protocol.
Reprod Health
December 2024
Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium.
Background: Tanzania, like most low- and middle-income countries, is facing an increasing prevalence of obesity in the general population, including among women of reproductive age. Excess weight pre-pregnancy is a risk factor for the onset of gestational diabetes mellitus (GDM), which is associated with several poor pregnancy outcomes. Screening for GDM, as a primary preventive measure, is not systematically done in Tanzania.
View Article and Find Full Text PDFDoes living in a food desert impact weight loss after bariatric surgery?
Surg Obes Relat Dis
November 2024
Division of Bariatric and Gastrointestinal Surgery, Virginia Commonwealth University, Richmond, Virginia. Electronic address:
Background: Lower access to fresh foods and lower income level are associated with greater obesity rates.
Objectives: We aim to study if weight loss 1 year after bariatric surgery is associated with living in areas defined as food deserts, that is, low access to foods and lower income.
Setting: Virginia Commonwealth University Hospital System, Richmond, VA; Academic Center.
Introduction: Childhood obesity and physical inactivity rates in Mexico are among the highest in the world. While parenting is a key factor in shaping children's physical activity behavior, there is a lack of research in this area, particularly in Mexico.
Objective: This qualitative study aims to better understand aspects of parenting relevant to children's physical engagement, including what parents understand by physical activity, how engaged they are and how important they find it, that is, their physical literacy.
Gastric ultrasound: Enhancing preoperative risk assessment and patient safety.
J Perioper Pract
December 2024
Concord Repatriation General Hospital, Sydney, NSW, Australia.
Perioperative pulmonary aspiration is a critical complication linked to significant morbidity and mortality, particularly in high-risk populations such as patients with diabetes, obesity, gastroparesis, or those using Glucagon-Like-Peptide-1 receptor agonists (GLP-1 RAs). Standard fasting protocols may not be appropriate for these patients, as they have increased propensity of delayed gastric emptying, hence increasing the complex of the preoperative risk assessment. Gastric ultrasound (GUS) provides a non-invasive, reliable method for assessing gastric content and volume, enabling anaesthesia professionals to make informed decisions regarding aspiration risk, airway management, and surgical scheduling.
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