Objectives: In this paper, we study the development and domain-adaptation of statistical syntactic parsers for three different clinical domains in Finnish.
Methods And Materials: The materials include text from daily nursing notes written by nurses in an intensive care unit, physicians' notes from cardiology patients' health records, and daily nursing notes from cardiology patients' health records. The parsing is performed with the statistical parser of Bohnet (http://code.google.com/p/mate-tools/, accessed: 22 November 2013).
Results: A parser trained only on general language performs poorly in all clinical subdomains, the labelled attachment score (LAS) ranging from 59.4% to 71.4%, whereas domain data combined with general language gives better results, the LAS varying between 67.2% and 81.7%. However, even a small amount of clinical domain data quickly outperforms this and also clinical data from other domains is more beneficial (LAS 71.3-80.0%) than general language only. The best results (LAS 77.4-84.6%) are achieved by using as training data the combination of all the clinical treebanks.
Conclusions: In order to develop a good syntactic parser for clinical language variants, a general language resource is not mandatory, while data from clinical fields is. However, in addition to the exact same clinical domain, also data from other clinical domains is useful.
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http://dx.doi.org/10.1016/j.artmed.2014.02.002 | DOI Listing |
Behav Res Methods
January 2025
Institute of Developmental Psychology, Faculty of Psychology, Beijing Normal University, No.19 Xinjiekouwai Street, Haidian District, Beijing, 100875, China.
Over the past few decades, Swahili-English and Lithuanian-English word pair databases have been extensively utilized in research on learning and memory. However, these normative databases are specifically designed for generating study stimuli in learning and memory research involving native (or fluent) English speakers. Consequently, they are not suitable for investigations that encompass populations whose first language is not English, such as Chinese individuals.
View Article and Find Full Text PDFBrief Bioinform
November 2024
Department of Computer Science, Hunan University, Changsha 410008, China.
Recently, the impressive performance of large language models (LLMs) on a wide range of tasks has attracted an increasing number of attempts to apply LLMs in drug discovery. However, molecule optimization, a critical task in the drug discovery pipeline, is currently an area that has seen little involvement from LLMs. Most of existing approaches focus solely on capturing the underlying patterns in chemical structures provided by the data, without taking advantage of expert feedback.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Washington University School of Medicine, St. Louis, MO, USA.
Background: Alzheimer disease (AD) involves neurodegenerative disorders with progressive cognitive decline. Atypical presentations like Posterior Cortical Atrophy (PCA) and Logopenic Variant Primary Progressive Aphasia (lvPPA) exhibit distinct clinical profiles. PCA affects the posterior parietal and occipital lobes, causing visuospatial deficits, while lvPPA manifests as language impairment in the temporoparietal region.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Background: Currently, it is unclear to what extent late-onset Alzheimer's disease (AD) risk variants contribute to early-onset AD (EOAD). One method to clarify the contribution of late-onset AD genetic risk to EOAD is to investigate the association of AD polygenic risk scores (PRS) with EOAD. We hypothesize that in the Longitudinal Early-Onset Alzheimer's Disease Study (LEADS), EOAD participants will have greater PRS than early-onset amyloid-negative cognitively-impaired participants (EOnonAD) and controls, and investigate the association of AD PRS with age of disease onset (AoO) and cognitive performance.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Boston University Alzheimer's Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Background: There is growing evidence that epigenetic age acceleration may predict late life cognitive decline and dementia, but it is unknown whether this is due to accelerated neurodegeneration or reduction in cognitive resilience. We examined the relationship between epigenetic clocks and domain specific neuropsychological (NP) factor scores, mild cognitive impairment (MCI), Alzheimer's Disease (AD), and all-cause dementia, before and after accounting for plasma total tau (t-tau), a marker of neurodegeneration.
Method: DNA methylation and plasma t-tau (Simoa assay; Quanterix) data from 2091 Framingham Heart Study Offspring cohort participants were generated from blood at the same Exam 8 visit (2005-2008).
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