AI Article Synopsis
- From 1969 to 1980, 68 children with Hodgkin's disease were treated with a combination of MVPP chemotherapy and radiotherapy, achieving remission in 64 cases, while 11 experienced relapses.
- The relapsed patients were treated with B-DOPA alone or combined with MVPP and radiotherapy, with a recycling schedule every 2-3 weeks to complete early cycles in 4.5 to 7 months.
- Currently, eight children are disease-free after experiencing relapses, with a median survival time of 94.5 months, suggesting that aggressive chemotherapy is crucial for treating relapses in Hodgkin's disease.
Article Abstract
In the years 1969-1980, 68 children with Hodgkin's disease were subjected to a combined MVPP and radiotherapy. Remissions were obtained in 64 patients, and relapses occurred in 11 children. The treatment of relapse consisted in administration of B-DOPA alone or alternatively with MVPP combined with radiotherapy (in 7 out of 11 patients). The patients were recycled every 2-3 weeks which, with other modifications of chemotherapy, allowed for the completion of the six first cycles within the period of 4,5 to 7 months. A relapse caused death of one child, and two others demonstrated further relapses. At present eight children have been showing disease-free survival following a relapse for the period of 29+ to 152+ (median, 94.5 months). The authors concluded that in patients with relapses of Hodgkin's disease the decisive role rests upon aggressive chemotherapy (high frequency of cycles).
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