AI Article Synopsis
- Researchers have created polycations that can break down through the reduction of disulfide bonds, aimed at improving the delivery of nucleic acids in biomedical applications.
- The article reviews various methods for synthesizing these bioreducible polycations and explores how they work as bioreducible polyplexes.
- It highlights the impact of the biological redox environment on factors like toxicity, cellular movement, effectiveness of gene transfection, and overall behavior in living organisms.
Article Abstract
Polycations that are degradable by reduction of disulfide bonds are developed for applications in delivery of nucleic acids. This Feature Article surveys methods of synthesis of bioreducible polycations and discusses current understanding of the mechanism of action of bioreducible polyplexes. Emphasis is placed on the relationship between the biological redox environment and toxicity, trafficking, transfection activity, and in vivo behavior of bioreducible polycations and polyplexes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410047 | PMC |
| http://dx.doi.org/10.1002/mabi.201400061 | DOI Listing |
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