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Moving Forward on Tumor Pathology Research Reporting: A Guide for Pathologists From the World Health Organization Classification of Tumors Living Evidence Gap Map by Tumour Type Group.
Mod Pathol
July 2024
International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France.
Evidence-based medicine (EBM) can be an unfamiliar territory for those working in tumor pathology research, and there is a great deal of uncertainty about how to undertake an EBM approach to planning and reporting histopathology-based studies. In this article, reviewed and endorsed by the Word Health Organization International Agency for Research on Cancer's International Collaboration for Cancer Classification and Research, we aim to help pathologists and researchers understand the basics of planning an evidence-based tumor pathology research study, as well as our recommendations on how to report the findings from these. We introduce some basic EBM concepts, a framework for research questions, and thoughts on study design and emphasize the concept of reporting standards.
View Article and Find Full Text PDFClinical Confirmation of Pan-Amyloid Reactivity of Radioiodinated Peptide I-p5+14 (AT-01) in Patients with Diverse Types of Systemic Amyloidosis Demonstrated by PET/CT Imaging.
Pharmaceuticals (Basel)
April 2023
Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN 37920, USA.
Article Synopsis
- There are at least 20 types of systemic amyloidosis, characterized by harmful amyloid deposits accumulating in organs, making early diagnosis vital for positive patient outcomes.
- A new peptide, p5+14, has been developed to non-invasively detect all types of amyloid in the body, aiming to identify at-risk individuals early.
- Clinical trials using iodine-124-labeled p5+14 show promising results, as it effectively binds to amyloid in patients, confirming its potential for accurate amyloidosis diagnosis through PET/CT imaging.
The role of patient advocates and sarcoma community initiatives in musculoskeletal oncology. Moving towards Evidence-Based Advocacy to empower Evidence-Based Medicine.
J Cancer Policy
June 2023
Sarcoma Patient Advocacy Global Network (SPAGN), Germany. Electronic address:
Musculoskeletal sarcomas are rare cancers that as the whole family of sarcomas pose several challenges at different levels, ranging from medical knowledge to clinical research and policymaking. Addressing these challenges, necessarily calls for the inclusion of patient perspective inside the decision-making processes of every area that contributes to treatment improvement, from the provision of high-quality services by healthcare organisations to research issues. Without patient-provided inputs to inform decisions, the current paradigm of patient-centred care makes no sense and sounds at the least irrational if not unethical.
View Article and Find Full Text PDFThe research escape hunt: An escape room-scavenger hunt for resident education.
AEM Educ Train
December 2022
Department of Emergency Medicine Maine Medical Center, Tufts University School of Medicine Portland Maine USA.
Objectives: Research and evidence-based medicine (EBM) education are important elements of emergency medicine (EM) residency training; however, curricular time is limited and integrating novel strategies to engage learners and improve understanding of complex concepts is challenging. We sought to develop a unique research escape hunt educational experience to teach EM residents basic research and EBM skills using an active-learning, team-based strategy.
Methods: A nine-station escape room-scavenger hunt was designed around educational content including (1) predictive statistics and diagnostic test characteristics, (2) interpretation of data and statistical analysis, (3) study design, (4) informed consent for research, and (5) the ethical principles guiding research.
An overview on the promotion on patient-centered care and shared decision-making in Mexico.
Z Evid Fortbild Qual Gesundhwes
June 2022
Departamento de Investigación en Sistemas de Salud, Instituto de Ciencias de la Salud, Universidad Veracruzana, México. Electronic address:
Mexico is a mid-income North American country. It strives to materialize the right to health in accordance with its laws. But the health system faces various problems: fragmentation, segmentation, limited funding, insufficient coverage, and low quality of health care.
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