Objectives: The aim of this work was to evaluate the effect of long term supplementation with two moderate dose of Zn on plasma and cellular red-ox status markers in elderly volunteers.
Design, Setting And Subjects: In a double blind study 108 healthy volunteers, aged 70-85 years, were enrolled. They were randomly divided in 3 groups of treatment, receiving placebo, 15 mg/day and 30 mg/day of Zn for 6 months. Red-ox status markers were assessed at baseline and after 6 months evaluating carotenoids, vitamin A and E in plasma; glutathione (GSH), thiol groups (RSH), malondialdehyde (MDA), percentage of haemolysis and methemoglobin in erythrocytes.
Results: Zn supplementation had no significant effects on red-ox status markers except for vitamin A levels (from 1.94±0.44 to 2.18±0.48 μM in volunteers receiving 15 mg of Zn and from 1.95±0.46 to 2.26±0.56 μM in volunteers receiving 30 mg of Zn), which increased proportionally to zinc dose.
Conclusions: It appears that, differently from unhealthy populations, long-term supplementation with two moderate doses of Zn in a healthy elderly population, with an adequate Zn nutritive status and macro and micronutrients intakes in the range of normality, is an inefficient way to increase antioxidant defences.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12603-014-0005-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A role for ceruloplasmin in the control of human glioblastoma cell responses to radiation.
BMC Cancer
August 2022
Université d'Angers, Inserm UMR 1307, CNRS UMR 6075, Nantes Université, CRCI2NA, F-49000, Angers, France.
Article Synopsis
- Glioblastoma (GB) is a highly aggressive brain tumor, and its growth depends on iron metabolism, which may influence the effectiveness of radiation therapy.
- Recent studies found that the expression of ceruloplasmin (CP), a key iron regulator, changes in response to radiation, prompting an investigation of how CP affects GB cell responses to radiation under varying oxygen levels.
- The findings reveal that manipulating CP expression in GB cell lines affects cell survival and DNA repair mechanisms, suggesting that higher CP levels enhance the effectiveness of radiotherapy on GB cells.
Oxidative Damage of Blood Platelets Correlates with the Degree of Psychophysical Disability in Secondary Progressive Multiple Sclerosis.
Oxid Med Cell Longev
May 2021
Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 41/143, 90-236 Lodz, Poland.
The results of past research studies show that platelets are one of the main sources of reactive oxygen species (ROS) and reactive nitrogen species (RNS) to be found in the course of many pathological states. The aim of this study was to determine the level of oxidative/nitrative stress biomarkers in blood platelets obtained from multiple sclerosis (MS) patients ( = 110) and to verify their correlation with the clinical parameters of the psychophysical disability of patients. The mitochondrial metabolism of platelets was assessed by measuring the intracellular production of ROS using the fluorescence method with DCFH-DA dye and by identification of changes in the mitochondrial membrane potential of platelets using the JC-1 dye.
View Article and Find Full Text PDFIs maternal dietary selenium intake related to antioxidant status and the occurrence of pregnancy complications?
J Trace Elem Med Biol
July 2019
Department of Food Science and Dietetics, Wroclaw Medical University, Borowska 211, 50-556, Wroclaw, Poland.
Selenium (Se) is a trace element essential for the appropriate course of vital processes in the human body. It is also a constituent of the active center of glutathione peroxidase and other antioxidant compounds which play an important role in red-ox processes. Associations between lower blood selenium concentration and obstetric complications has been reported in many studies.
View Article and Find Full Text PDFRedox Mediators for Li-O Batteries: Status and Perspectives.
Adv Mater
January 2018
Department of Energy Engineering, Hanyang University, Seoul, 133-791, South Korea.
Li-O batteries have received much attention due to their extremely large theoretical energy density. However, the high overpotentials required for charging Li-O batteries lower their energy efficiency and degrade the electrolytes and carbon electrodes. This problem is one of the main obstacles in developing practical Li-O batteries.
View Article and Find Full Text PDFMarkers of oxidative/nitrative damage of plasma proteins correlated with EDSS and BDI scores in patients with secondary progressive multiple sclerosis.
Redox Rep
November 2017
a Faculty of Biology and Environmental Protection, Department of General Biochemistry , University of Lodz, Lodz , Poland.
Objectives: The objective of the present study was to evaluate oxidative/nitrative stress in the plasma of 50 patients suffering from the secondary progressive course of multiple sclerosis (MS), and to verify its correlation with physical and mental disability as assessed by the Expanded Disability Status Scale (EDSS), and the Beck Depression Inventory (BDI).
Methods: Oxidative and nitrative damage to proteins was determined by the level of carbonyl groups and 3-nitrotyrosine using ELISA test. Based on the reaction with Ellman's reagent, we estimated the concentration of oxidized thiol groups.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!