AI Article Synopsis
- The TITRe2 trial is a multi-centre randomised controlled study in the UK, involving 2000 cardiac surgery patients, testing whether restrictive transfusion thresholds lead to better outcomes compared to liberal ones.
- Randomization occurs only for patients whose hemoglobin drops below 9 g/dL after surgery, with the study focusing on serious events within three months.
- The study has faced various challenges during its setup and implementation.
Article Abstract
Thresholds for red blood cell transfusion following cardiac surgery vary by hospital and surgeon. The TITRe2 multi-centre randomised controlled trial aims to randomise 2000 patients from 17 United Kingdom centres, and tests the hypothesis that a restrictive transfusion threshold will reduce postoperative morbidity and health service costs compared to a liberal threshold. Patients consent to take part in the study pre-operatively but are only randomised if their haemoglobin falls below 9 g/dL during their post-operative hospital stay. The primary outcome is a binary composite outcome of any serious infectious or ischaemic event in the first three months after randomisation. Many challenges have been encountered in the set-up and running of the study.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064699 | PMC |
| http://dx.doi.org/10.1016/j.transci.2014.02.020 | DOI Listing |
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