In Morocco, acute Atractylis gummifera L. poisoning represents the leading cause of death by plant poisoning especially for children. All cases received in the Moroccan poison control centre from January 1981 to December 2009 (n = 467) were included in a retrospective study of the characteristics and risk factors of A. gummifera L. poisoning. The most vulnerable age group was children (63.4% of cases). Most cases were due to accidental exposure (75.5%), but some were from therapeutic use (18.1%) or attempted abortion (7.4%). Patients presented with moderate poison severity signs (grade 2) in 22.3% of cases or severe signs (grade 3) in 21.0%. The mortality rate was 39.2%. The majority of deaths (81.1%) occurred in children aged < 15 years following accidental exposure. Multivariate logistic regression analysis revealed that risk factors for mortality were coma (OR = 20.5); hepatitis (OR = 52.7) and rural residence (OR = 7.26), while gastric decontamination was a protector factor (OR = 0.26).
Download full-text PDF |
Source |
---|
Afr Health Sci
March 2024
Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Ege University, 35040 Bornova-İzmir, Turkey.
Background: The Mediterranean thistle L. (Asteraceae; AG) has diterpenoid glucosides; atractyloside and carboxyatractyloside that interact with mitochondrial protein adenine nucleotide translocator (ANT) and resulted in ATP inhibition. Despite its well-known toxicity, acute poisonings still occur with this plant.
View Article and Find Full Text PDFMed Leg J
June 2023
Medico-legal Department, Ibn Sina University Hospital, Rabat, Morocco.
Atractylis gummifera L. is a wild poisonous plant found in rural areas around the Mediterranean. It is also available from herbalists.
View Article and Find Full Text PDFAm J Forensic Med Pathol
September 2021
Medico-legal Institute, Ibn Rochd University Hospital, Hassan II University, Faculty of Medicine and Pharmacy, Casablanca.
Background: Atractylis gummifera L. is a poisonous thistle plant that grows in the Mediterranean regions especially in northern Africa like Morocco and southern Europe. It has been used frequently to treat some diseases in traditional medicine, and its ingestion is a common cause of fatal poisoning.
View Article and Find Full Text PDFJ Ethnopharmacol
May 2020
Laboratory of Pharmacology and Toxicology, Biopharmaceutical and Toxicological Analysis Research Team, Faculty of Medicine and Pharmacy, Mohammed V University, BP 6203, Rabat-Institutes, Rabat, Morocco. Electronic address:
Ethnopharmacological Relevance: Atractylis gummifera is a toxic plant widely used in Mediterranean traditional medicine against colds, dizziness, and headaches, as an antisyphilitic, against boils, as a purgative, emetic and deworming. All studies reported on this plant have been carried out either on the plant and its traditional uses, or on cases of poisoning by this plant. However, few pharmacological studies have readjusted the traditional uses of this plant.
View Article and Find Full Text PDFCurr Drug Saf
January 2020
Faculty of Sciences and Techniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, Errachidia, 52000, Morocco.
Background: Several botanical species are poisonous and are used for medicinal purposes in traditional medicine. In fact, a relationship between toxicity and phytotherapeutic potential of medicinal plants exists.
Objective: Until now, there is no ethnopharmacological indices evaluating mathematically the toxic property of any medicinal plant used traditionally.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!