AI Article Synopsis
- Helicobacter pylori infection is a major contributor to the development of gastric cancer, with infected individuals showing a higher incidence of the disease compared to those who are not infected.
- In studies with rodents, while H. pylori alone causes certain gastric lesions, its presence significantly promotes cancer development when the animals are also treated with carcinogens.
- Eradicating H. pylori is beneficial in preventing gastric cancer, especially if there is only mild inflammation, and research into chemoprevention suggests that certain medications and candidate chemicals could be effective in humans in the future.
Article Abstract
Helicobacter pylori infection is one of the most important factors in gastric carcinogenesis in humans. Epidemiological studies have revealed that H. pylori-infected patients develop significantly more gastric cancers than uninfected individuals. In rodent models, H. pylori inoculation causes strong promoting effects in carcinogen-treated animals, whereas the bacterial infection alone causes only hyperplasic, atrophic, and/or metaplastic lesions. In both human and rodent models, eradication of H. pylori helps inhibit gastric carcinogenesis, especially when there is only mild gastric inflammation and no evidence of severe atrophy or intestinal metaplasia. Chemoprevention studies in humans have been reported and have shown the effectiveness of several medications including a cyclooxygenase-2 inhibitor. Candidate chemicals used in rodent models could hopefully be used in humans in the future.
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| http://dx.doi.org/10.1007/s11908-014-0402-4 | DOI Listing |
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