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Long-Term SGRQ Stability in a Cohort of Individuals with Alpha-1 Antitrypsin Deficiency-Associated Lung Disease.
Int J Chron Obstruct Pulmon Dis
April 2024
Alphanet, Inc., Coral Gables, Florida, USA.
Background: Health-related quality of life (HRQoL) assessments such as St. George's Respiratory Questionnaire (SGRQ) are often used as outcome measures to evaluate patient-perceived changes in health status among individuals with lung disease. Several factors have been linked to deterioration in SGRQ, including symptoms (dyspnea, wheezing) and exercise intolerance.
View Article and Find Full Text PDFReduction of false positives using zone-specific prostate-specific antigen density for prostate MRI-based biopsy decision strategies.
Eur Radiol
October 2024
Department of Radiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Article Synopsis
- The study aimed to improve prostate cancer biopsy decision strategies by combining zone-specific prostate-specific antigen density (sPSAD) with the PI-RADS system.
- Using a deep learning system, researchers segmented MRI images to calculate sPSAD for the whole gland and transition zone, yielding better detection rates for significant prostate cancer compared to traditional methods.
- The findings indicated that adopting sPSAD reduced false positives and enhanced specificity in biopsy decisions, particularly in cases classified as PI-RADS 3, while still maintaining high sensitivity for detecting more serious cancer cases.
Pulmonary Hypertension: Intensification and Personalization of Combination Rx (PHoenix): A phase IV randomized trial for the evaluation of dose-response and clinical efficacy of riociguat and selexipag using implanted technologies.
Pulm Circ
January 2024
Division of Clinical Medicine University of Sheffield Sheffield UK.
Approved therapies for the treatment of patients with pulmonary arterial hypertension (PAH) mediate pulmonary vascular vasodilatation by targeting distinct biological pathways. International guidelines recommend that patients with an inadequate response to dual therapy with a phosphodiesterase type-5 inhibitor (PDE5i) and endothelin receptor antagonist (ERA), are recommended to either intensify oral therapy by adding a selective prostacyclin receptor (IP) agonist (selexipag), or switching from PDE5i to a soluble guanylate-cyclase stimulator (sGCS; riociguat). The clinical equipoise between these therapeutic choices provides the opportunity for evaluation of individualized therapeutic effects.
View Article and Find Full Text PDFSurgical outcomes of cytoreductive nephrectomy in patients receiving systemic immunotherapy for advanced renal cell carcinoma.
Urol Oncol
February 2024
Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:
Article Synopsis
- Doctors are using a type of treatment called systemic immune checkpoint blockade before surgery for kidney cancer patients, but they didn't know much about how safe it was after this treatment.
- They looked at 220 patients who had kidney surgery; 46 of them received immunotherapy before their operations.
- The results showed that having immunotherapy before surgery didn't lead to more complications, but those patients were more likely to need a blood transfusion afterward.
Treating Depression in Adolescents and Young Adults Using Remote Intensive Outpatient Programs: Quality Improvement Assessment.
JMIR Form Res
April 2023
Charlie Health, Inc, Bozeman, MT, United States.
Background: Youth and young adults face barriers to mental health care, including a shortage of programs that accept youth and a lack of developmentally sensitive programming among those that do. This shortage, along with the associated geographically limited options, has contributed to the health disparities experienced by youth in general and by those with higher acuity mental health needs in particular. Although intensive outpatient programs can be an effective option for youth with more complex mental health needs, place-based intensive outpatient programming locations are still limited to clients who have the ability to travel to the clinical setting several days per week.
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