The sensitivity of ram erythrocyte-specific B-cells to cyclophosphane was studied. An antigen and two polyclonal activators, lipopolysaccharide and dextran sulfate, were used as the clone activators. The immunodepressant effect of cyclophosphane was found to depend on the degree of the immunocompetent clone activation. The maximal elimination of the clone under the influence of cyclophosphane occurred after its activation by the antigen and lipopolysaccharide. The drug exerted the minimal effect on the "resting" clone. The degree of suppression of the clone activated by dextran sulfate took the intermediate position.
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