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Effect of infection on immunotherapy for gastrointestinal cancer: a narrative review.
Immunotherapy
March 2025
Department of Medical Oncology, Metaxa Cancer Hospital of Piraeus, Piraeus, Greece.
Immunotherapy for gastrointestinal cancers has elicited considerable amount of attention as a viable therapeutic option for several cancer types. Gut microbiome as a whole plays a critical role in shaping immune responses and influencing cancer progression. Recent evidence suggests that (), may influence immunotherapy efficacy by modulating the tumor microenvironment.
View Article and Find Full Text PDFUncovering Chemical Principles Governing Nanophase Formation in Ternary Solvents.
Angew Chem Int Ed Engl
March 2025
Penn State University, Chemistry, 104 Chemistry, 16802, University Park, UNITED STATES OF AMERICA.
Nanoscopic phases, such as oil-enriched pockets dispersed in water, have been observed in ternary mixtures of oil, water, and cosolvent in the absence of surfactants. Such nanophases are found across a portion of compositions within the single-phase region of the ternary phase diagram. However, the principles governing the formation of nanophases under certain conditions but not others, regarding both volumetric and chemical makeup, are unclear.
View Article and Find Full Text PDFStem Cells from Human Exfoliated Deciduous Teeth-Derived Exosomes for the Treatment of Acute Liver Injury and Liver Fibrosis.
ACS Appl Mater Interfaces
March 2025
Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
Mesenchymal stem cells (MSCs) play a crucial role in regenerative medicine due to their regenerative potential. However, traditional MSC-based therapies are hindered by issues such as microvascular obstruction and low cell survival after transplantation. Exosomes derived from MSCs (MSC-Exo) provide a cell-free, nanoscale alternative, mitigating these risks and offering therapeutic potential for liver diseases.
View Article and Find Full Text PDFStreamlined and efficient genome editing in Cupriavidus necator H16 using an optimised SIBR-Cas system.
Trends Biotechnol
March 2025
Laboratory of Microbiology, Wageningen University and Research, Wageningen, The Netherlands; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany; LSC-EMBL Partnership Institute for Genome Editing Technologies, Life Sciences Center, Vilnius University, Vilnius, Lithuania. Electronic address:
Cupriavidus necator H16 is a promising microbial platform strain for CO valorisation. While C. necator is amenable to genome editing, existing tools are often inefficient or rely on lengthy protocols, hindering its rapid transition to industrial applications.
View Article and Find Full Text PDFRole of artificial intelligence in magnetic resonance imaging-based detection of temporomandibular joint disorder: a systematic review.
Br J Oral Maxillofac Surg
December 2024
Department of Radiodiagnosis and Imaging, LNMC & JK Hospital, Bhopal, India.
This systematic review aimed to evaluate the application of artificial intelligence (AI) in the identification of temporomandibular joint (TMJ) disc position in normal or temporomandibular joint disorder (TMD) individuals using magnetic resonance imaging (MRI). Database search was done in Pub med, Google scholar, Semantic scholar and Cochrane for studies on AI application to detect TMJ disc position in MRI till September 2023 adhering PRISMA guidelines. Data extraction included number of patients, number of TMJ/MRI, AI algorithm and performance metrics.
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