Unlabelled: Careful prescribing is paramount in clinical practice. Potential drug-drug interactions need to be considered. Midazolam is the drug of choice for the purpose of IV sedation. To ensure safe clinical practice, the patient's current medications need to be recorded.
Clinical Relevance: An update on the drug interactions relating to midazolam are worthy of scrutiny as its use becomes more commonplace in clinical practice.
Objective: The dentist should understand the possible implications for drug interactions when sedating patients using midazolam.
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Safety, bactericidal activity, and pharmacokinetics of the antituberculosis drug candidate BTZ-043 in South Africa (PanACEA-BTZ-043-02): an open-label, dose-expansion, randomised, controlled, phase 1b/2a trial.
Lancet Microbe
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Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Germany; German Center for Infection Research, Munich Partner Site, Munich, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection, and Pandemic Research, Munich, Germany; Unit Global Health, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. Electronic address:
Background: The broad use of bedaquiline and pretomanid as the mainstay of new regimens to combat tuberculosis is a risk due to increasing bedaquiline resistance. We aimed to assess the safety, bactericidal activity, and pharmacokinetics of BTZ-043, a first-in-class DprE1 inhibitor with strong bactericidal activity in murine models.
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