Background: postoperative nausea and vomiting (PONV) frequently hampers implementation of ambulatory surgery in spite of so many antiemetic drugs and regimens.
Aims: the study was carried out to compare the efficacy of Ramosetron and Ondansetron in preventing PONV after ambulatory surgery.
Setting And Design: it was a prospective, double blinded, and randomized controlled study.
Methods: 124 adult patients of either sex, aged 25-55, of ASA physical status I and II, scheduled for day care surgery, were randomly allocated into Group A [(n=62) receiving (IV) Ondansetron (4 mg)] and Group B [(n=62) receiving IV Ramosetron (0.3 mg)] prior to the induction of general anesthesia in a double-blind manner. Episodes of PONV were noted at 0.5, 1, 2, 4 h, 6, 12, and 18 h postoperatively.
Statistical Analysis And Results: statistically significant difference between Groups A and B (P <0.05) was found showing that Ramosetron was superior to Ondansetron as antiemetic both regarding frequency and severity.
Conclusion: it was evident that preoperative prophylactic administration of single dose IV Ramosetron (0.3 mg) has better efficacy than single dose IV Ondansetron (4 mg) in reducing the episodes of PONV over 18 h postoperatively in patients undergoing day-care surgery under general anesthesia.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950448 | PMC |
| http://dx.doi.org/10.4103/1658-354X.125917 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Day surgery in children: 15-year analysis of unplanned admissions at a Japanese tertiary children's hospital.
J Anesth
December 2024
Department of Anesthesiology, Aichi Children's Health and Medical Center, 7-426 Morioka, Obu, Aichi, 474-8710, Japan.
Purpose: Unplanned hospital admission following pediatric day surgery is a crucial quality indicator. This study examined the incidence, related risks, interventions, and outcomes of unplanned hospital admission following pediatric day surgery among children in Japan.
Methods: This single-center, retrospective study analyzed data of 14,529 pediatric patients under the age of 18 years who underwent day surgery between August 2007 and December 2022.
Postoperative Nausea and Vomiting Management for Adults in the Ambulatory Surgical Setting.
Int Anesthesiol Clin
January 2025
Department of Anesthesiology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania.
A comprehensive analysis of in-hospital adverse events after scopolamine administration: insights from a retrospective cohort study using a large nationwide inpatient database.
BMC Anesthesiol
November 2024
Department of Anesthesiology and Perioperative Medicine, Thomas Jefferson University, 111 S 11th St Gibbon Building, Philadelphia, PA, 8330, 19107, USA.
Background: Scopolamine is a widely used antiemetic in anesthetic practice, particularly for postoperative and post-discharge nausea and vomiting. Despite its frequent usage and recognized efficacy, concerns have emerged regarding the potential for increased side effects, particularly in elderly patients. Further research is needed to assess safety and determine age thresholds for adverse events.
View Article and Find Full Text PDFComparison of a single intravenous infusion of alfentanil or sufentanil combined with target-controlled infusion of propofol for daytime hysteroscopy: a randomized clinical trial.
Ther Adv Drug Saf
October 2024
Department of Anesthesiology, Women and Children's Hospital of Chongqing Medical University (Chongqing Health Center for Women and Children), 120 Longshan Road, Yubei District, Chongqing 401147, China.
Article Synopsis
- The study compares the safety and efficacy of two anesthetic medications, alfentanil and sufentanil, used during daytime hysteroscopy alongside target-controlled infusion (TCI) of propofol.
- A total of 160 patients were randomly assigned to receive either alfentanil or sufentanil, and various health metrics including hypoxemia and postoperative nausea/vomiting were monitored.
- Results indicated that alfentanil resulted in fewer incidents of hypoxemia and postoperative complications, suggesting it may be a safer option compared to sufentanil for this procedure.
Music-Based Therapy for the Treatment of Perioperative Anxiety and Pain-A Randomized, Prospective Clinical Trial.
J Clin Med
October 2024
Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
: Music-based intervention has been advocated as a nonpharmacologic approach for the perioperative control of pain and anxiety in surgical patients. However, its impact on patients with preoperative anxiety has not been clearly established. Our study aimed to examine the impact of music-based intervention administered before, during, and after surgery on postoperative opioid consumption and pain levels, as well as preoperative anxiety, depression, and pain catastrophizing.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!