AI Article Synopsis
- Diabetic retinopathy (DR) is typically seen as a complication involving small blood vessels in the eyes of diabetics, but recent studies show that it also affects retinal neuron function and survival.
- A chemical hypoxia model, which simulates advanced diabetes stages, offers an affordable and efficient alternative for studying retinal cell behavior compared to traditional diabetic animal models.
- This chapter compares diabetic models and hypoxic conditions, highlighting the advantages and drawbacks of using a cobalt-chloride hypoxia system in mice for understanding how diabetes impacts retinal neurons.
Article Abstract
Diabetic retinopathy (DR) is traditionally considered as a microvascular complication in diabetic retinas. Emerging evidences suggest that the alteration of neuronal function and the death of retinal neurons are part of DR pathology. However, surprisingly little is known about how retinal neurons behave in DR. As diabetic animals are chronicle models that are difficult and expensive to maintain, we used a chemical hypoxia model that mimics the later stage of diabetes and investigated its potential in predicting retinal cell behaviors in diabetes in an efficient manner. In this chapter, we discuss the similarities and differences between diabetic and hypoxic models and the usefulness and limitation of the cobalt-chloride-generated hypoxia system in mice for studying retinal neurobiology in diabetes.
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| http://dx.doi.org/10.1007/978-1-4614-3209-8_18 | DOI Listing |
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