AI Article Synopsis
- - EHD2 is a protein that plays a key role in vesicular trafficking and endocytosis, but its role in central nervous system diseases is not well understood.
- - Research showed that after intracerebral hemorrhage (ICH) in rats, EHD2 levels increased in the brain area affected and was found alongside neurons and activated microglia.
- - The study indicated a connection between EHD2 and neuronal cell death, as well as microglial activity, suggesting EHD2 could be involved in the mechanisms of ICH.
Article Abstract
EHD2, a member of the Eps15 homology domain (EH domain) family, is important for protein interactions during vesicular trafficking. Previous studies have proved that EHD2 can regulate trafficking from the plasma membrane in the process of endocytosis. However, its function in central nervous system diseases is still with limited understanding. In this frame, we found that EHD2 expression was upregulated in the perihematomal caudate in adult rats after intracerebral hemorrhage (ICH). Double immunofluorescence staining revealed that EHD2 was colocalized with neurons and activated microglias after ICH. Besides, we detected that neuronal apoptosis markers (TUNEL and caspase-3), and microglial activation marker (CD68), also known as a marker of macrophage, were colocated with EHD2. The vitro study also indicated that EHD2 was linked with neuronal apoptosis and microglial phagocytosis. All our findings suggested that EHD2 might be involved in the pathophysiology of ICH.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12031-014-0271-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Vascular dementia (VaD) refers to a variety of dementias driven by cerebrovascular disease and is the second leading cause of dementia globally. VaD may be caused by ischemic strokes, intracerebral hemorrhage, and/or cerebral small vessel disease, commonly identified as white matter hyperintensities on MRI. The mechanisms underlying these white matter lesions in the periventricular brain are poorly understood.
View Article and Find Full Text PDFClinical Outcomes of Endovascular Coil Embolization for Ruptured Middle Cerebral Artery Aneurysms.
J Neuroendovasc Ther
October 2024
Department of Neurosurgery & Stroke, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Objective: Middle cerebral artery (MCA) aneurysms are difficult to treat with coil embolization (CE) due to their location and shape, but the number of CE-treated MCA has gradually increased as treatment techniques have improved. However, the outcomes of CE for ruptured MCA aneurysms are poorly understood. This study aimed to evaluate the outcomes of CE for ruptured MCA aneurysms.
View Article and Find Full Text PDFCharacteristics of Mortality After Endovascular Thrombectomy in Patients with Acute Ischemic Stroke.
Clin Interv Aging
December 2024
Department of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, People's Republic of China.
Purpose: Despite significant advancements in the treatment of acute ischemic stroke (AIS) with endovascular thrombectomy (EVT), post-EVT mortality remains a considerable concern. However, there is a lack of real-world epidemiological data delineating the characteristics of mortality for EVT, particularly in recent years following the widespread promotion of EVT treatment for stroke patients.
Methods: This multicenter, retrospective study collected data from 721 AIS patients who died following EVT across 33 hospitals in Sichuan Province, China, from January 2019 to September 2022.
Clinical characteristics and quality care indicators of pediatric stroke in a referral center of Colombia: eleven-year experience (pediastroke).
Front Neurol
December 2024
Servicio de Neurología, Fundación Valle del Lili, Cali, Colombia.
Objective: This study aims to describe clinical variables and quality care indicators in pediatric stroke management at a high-complexity pediatric care center in Latin America.
Methods: Retrospective study of patients with stroke, aged 2-18 years from 2011 to 2021. The principal outcomes were the mRs and mortality.
Background: The increasing clinical use of combining structural MRI (sMRI) with General Movements Assessment (GMA) or Hammersmith Infant Neurological Exam (HINE) before five months corrected age (CA) for early diagnosis of cerebral palsy (CP) lacks sufficient prognostic data for children with CP, especially those with Gross Motor Function Classification System (GMFCS) I.
Objective: Evaluate the predictive value of sMRI, GMA, and HINE individually and in combination for early CP diagnosis and assess accuracy across varying GMFCS levels in a regional cohort of preterm infants.
Methods: We performed sMRI between 39-44 weeks postmenstrual age and GMA and HINE between 12-18 weeks CA in 395 preterm infants born at ≤32 weeks' gestation across five NICUs in Greater Cincinnati.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!