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| http://dx.doi.org/10.1177/0009922814528038 | DOI Listing |
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Intraoperative HIFU ablation of the liver at the hepatocaval confluence as adjunct to surgery: Preliminary animal experiments.
Ultrasonics
December 2024
LabTAU, INSERM, Centre Leon Berard, Universite Lyon 1, F-69003 LYON, France. Electronic address:
Treating colorectal liver metastases (CLMs) located at the hepatocaval confluence with surgery is challenging due to its complexity and associated high risks of perioperative mortality and morbidity. Moreover, thermal ablation techniques are sensitive to the "heat-sink" effect, which reduces their efficacy when tumors are in contact with major blood vessels. In this study we evaluated the feasibility and safety of an intraoperative high-intensity focused ultrasound (HIFU) device for destroying liver tissue volumes sufficiently large to consider treating CLMs at the hepatocaval confluence.
View Article and Find Full Text PDFEnergetic activity for depression in young people aged 13-17 years: the READY feasibility RCT.
Health Technol Assess
December 2024
Centre for Research in Public Health and Community Care, University of Hertfordshire, Hatfield, UK.
Article Synopsis
- The study aims to evaluate the feasibility of an exercise intervention for young people aged 13-17 with mild to moderate depression, comparing high-intensity exercise, low-intensity exercise, and social activities.
- Participants were recruited through mental health services and schools, with the intervention delivered over 12 weeks by trained professionals.
- Results showed a 71.4% retention rate and over 67% attendance, although only 14 participants were randomized from the initial referrals, indicating challenges in recruitment.
Personalized neoantigen hydrogel vaccine combined with PD-1 and CTLA-4 double blockade elicits antitumor response in liver metastases by activating intratumoral CD8CD69 T cells.
J Immunother Cancer
December 2024
The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian, P. R. China
Background: Liver metastasis is highly aggressive and immune tolerant, and lacks effective treatment strategies. This study aimed to develop a neoantigen hydrogel vaccine (NPT-gels) with high clinical feasibility and further investigate its efficacy and antitumor molecular mechanisms in combination with immune checkpoint inhibitors (ICIs) for the treatment of liver metastases.
Methods: The effects of liver metastasis on survival and intratumor T-cell subpopulation infiltration in patients with advanced tumors were investigated using the Surveillance, Epidemiology, and End Results Program (SEER) database and immunofluorescence staining, respectively.
Level of involvement of four selected cytochrome P450s (CYPs) in pyrethroid-resistant () and across Côte d'Ivoire.
Curr Res Parasitol Vector Borne Dis
October 2024
U.S. President's Malaria Initiative, Evolve Project, Washington DC, USA.
In Côte d'Ivoire, there is a high intensity of pyrethroid resistance in malaria vectors which may threaten successful vector control. Molecular studies of the target site mutation in the voltage-gated sodium channel (VGSC) show that the gene frequencies of these mutations are high, widely spread across Côte d'Ivoire, and even fixed in some areas. To further characterize insecticide resistance in Côte d'Ivoire beyond target site mutations, the metabolic resistance mechanism was explored.
View Article and Find Full Text PDFSurvival Outcomes and Recurrence Patterns Following Focal High-intensity Focused Ultrasound Treatment for Localized Prostate Cancer: Insights on Patient Selection and Lessons Learned.
Eur Urol Focus
November 2024
Desai Sethi Urology Institute, Miller School of Medicine, University of Miami, Miami, FL, USA.
Background And Objective: Focal therapy is increasingly being used as a treatment for localized prostate cancer (PC). Our aim was to evaluate oncological outcomes, recurrence patterns, and survival after high-intensity focused ultrasound (HIFU), to discuss the lessons learned from our experience, and to propose strategies to enhance patient selection for HIFU treatment.
Methods: Between 2016 and 2023, 113 patients underwent focal HIFU treatment for PC.
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