AI Article Synopsis
- Ferritin H is a key protein for iron storage that plays important roles in both early development and adult liver and intestine functions.
- Researchers used a genetic technique called Cre/loxP to create mice lacking ferritin H specifically in the forebrain.
- This deficiency led to cerebrospinal fluid buildup in the brain's lateral ventricles and subarachnoid space, while the overall iron content in brain tissue remained the same.
Article Abstract
Ferritin H, the major iron storage protein, has essential functions in early embryonic development as well as in adult liver and intestine. To address the question whether ferritin H has similarly essential functions in the brain we used the Cre/loxP system to generate mice with a forebrain-specific inactivation of the ferritin H gene. Ferritin H deficiency in most cells of the forebrain including cells of the choroid plexus caused accumulation of cerebrospinal fluid in the lateral ventricles and the subarachnoid space. Brain tissue iron content was unchanged.
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| http://dx.doi.org/10.1016/j.neuint.2014.03.010 | DOI Listing |
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