A new cucurbitane-type triterpene, 20, 21, 22, 23, 24, 25, 26, 27-octanorcucurbita-5-ene-3, 11, 16-trione (1), named kinoin D, was isolated from the roots of the medicinal plant Ibervillea sonorae, (wereque). The structure of 1 was established on the basis of extensive NMR and MS studies. In addition, the known kinoins B (3) and C (5) were isolated, as were 16alpha-20,25-trihydroxy-3alpha-(2-O-alpha-L-rhamnopyranosiyl-D-glucopyranosyloxy)-(10alpha)-cucurbit-5-en-11,22-dione (6), (22S)-16alpha,22-diacetoxy-20,25-dihydroxy-3alpha-[3,4,6-tri-O-acetyl-2-O-(2,3,4-tri-O-acetyl-alpha-L-rhamnopyranosyl)-beta-glucopyranosyl]-(10alpha)-cucurbita-5,23t-dien-11-one (7) and 16alpha-acetoxy-20,25-dihydroxy-3alpha-[3,4,6-tri-O-acetyl-2-O-(2,3,4,-tri-O-acetyl-alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl]-(10alpha)-cucurbita-5-ene-11,22-dione (8). Compound 1 exhibited anti-inflammatory activity in TPA-induced edema in mice.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Tumour growth inhibitory effect of phytopreparations in cervical cancer xenografts.
Nat Prod Res
August 2024
Departamento de Ciencias Químico Biológicas, Universidad de Sonora, Centro, Hermosillo Sonora, México.
Cucurbitacin IIb, a triterpene obtained from the plant, reduces tumour development in a preclinical model of cervical cancer. Acetison and Etanison, phytopreparations made from , present biological activity analogous to CIIb in HeLa. This research evaluated the tumour growth inhibitory effect of these phytopreparations in a HeLa xenograft tumour model in BALB/c nude mice.
View Article and Find Full Text PDFStandardized phytopreparations and cucurbitacin IIb from Ibervillea sonorae (S. Watson) greene induce apoptosis in cervical cancer cells by Nrf2 inhibition.
J Ethnopharmacol
November 2022
Departamento de Ciencias Químico Biológicas y de la Salud, Universidad de Sonora - Blvd. Luis Donaldo Colosio esq. Rosales S/N, Centro, Hermosillo Sonora, CP: 83000, Mexico. Electronic address:
Ethnopharmacology Relevance: Ibervillea sonorae (S. Watson) Greene is a plant from northwestern Mexico, known as "Wereke" or "Guareque", used by the Mayo ethnic group to treat diabetes and cancer. Cucurbitacin IIb (CIIb), isolated from I.
View Article and Find Full Text PDFSelected Species of the Cucurbitaceae Family Used in Mexico for the Treatment of Diabetes Mellitus.
Molecules
May 2022
Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, Ciudad de México 04510, Mexico.
In Mexico, Diabetes mellitus (DM) is a serious health problem, and although the current pharmacological treatments for DM such as insulin and oral hypoglycemics are available, the Mexican population continues to use medicinal plants in the treatment of DM. The antidiabetic properties of the plant species that belong to the Cucurbitaceae family has already been recognized worldwide. Since Mexico is one of the most important centers of diversity of Cucurbitaceae, the present work contributes to the review of the most used species of Cucurbitaceae in the treatment of DM in Mexico.
View Article and Find Full Text PDFIn Vitro Antitumor Activity of Endophytic and Rhizosphere Gram-Positive Bacteria from (S. Watson) Greene against L5178Y-R Lymphoma Cells.
Int J Environ Res Public Health
January 2022
Departamento de Microbiología e Inmunología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, San Nicolás de los Garza 66455, Mexico.
Plant-associated microorganisms represent a potential source of new antitumor compounds. The aim of the present study was to isolate endophytic and rhizosphere Gram-positive bacteria from and produce extracts with antitumor activity. Methanol and ethyl acetate extracts were obtained from 28 d bacterial fermentation, after which murine L5178Y-R lymphoma cells growth inhibition was evaluated at concentrations ranging from 15.
View Article and Find Full Text PDFAntiproliferative activity of standardized phytopreparations from Ibervillea sonorae (S. Watson) Greene.
Steroids
May 2021
Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquara - São Paulo, Brasil. Rodovia Araraquara - Jaú, Km 1 - CEP: 14800-903; Universidade Estadual Paulista (UNESP), Coastal Campus of São Vicente, São Vicente, SP Praça Infante Dom Henrique s/n, CEP 11330-205. Electronic address:
Ibervillea sonorae (Cucurbitaceae) is a medicinal plant utilized in Northwest Mexico against Diabetes and cancer. This natural product is taken orally, its presentation is capsules containing the plant's dried and powdered caudices. There is no regulation or standardized dosage that allows reproducibility of its pharmacological effects.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!