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Reconstruction of long-term hourly sea level data for Prince Edward Island, Canada.
Sci Data
January 2025
Canadian Centre for Climate Change and Adaptation, University of Prince Edward Island, St. Peters Bay, Prince Edward Island, C0A 2A0, Canada.
Regional sea level rise has been regarded a key factor in understanding of climate change impact to coastal communities. As a vulnerable island to sea level rise and storm surges, the province of Prince Edward Island (PEI) in Canada lacks sufficient long-term island-wide historic record of sea level data. This has become a major challenge for further studies on coastal environments and climate change adaptation.
View Article and Find Full Text PDFHurricanes, industrial animal operations, and acute gastrointestinal illness in North Carolina, USA.
Environ Res Health
March 2025
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, United States of America.
North Carolina (NC) ranks third among US states in both hog production and hurricanes. NC's hogs are housed in concentrated animal feeding operations (CAFOs) in the eastern, hurricane-prone part of the state. Hurricanes can inundate hog waste lagoons, transporting fecal bacteria that may cause acute gastrointestinal illness (AGI).
View Article and Find Full Text PDFA variety of autoimmune disorders are associated with an increased risk of thrombosis. Previous studies have suggested combined therapy of heparin and therapeutic plasma exchange (TPE) with fresh frozen plasma (FFP) as the replacement fluid is beneficial in some cases of acute flare-up of autoimmune diseases complicated by thrombotic events. Nevertheless, it remains unknown whether clinicians do more harm than good by exposing patients to a "thrombotic storm" through simultaneous administration of heparin and the clotting factors in the FFP during TPE.
View Article and Find Full Text PDFSweat chloride reflects CFTR function and correlates with clinical outcomes following CFTR modulator treatment.
J Cyst Fibros
January 2025
Cystic Fibrosis Therapeutics Development Network Coordinating Center, Seattle Children's Hospital, Seattle, WA, USA; Department of Pediatrics, University of Washington, Seattle, WA, USA; Department of Biostatistics, University of Washington, Seattle, WA, USA.
Background: Highly effective CFTR modulators improve CFTR function and lead to dramatic improvements in health outcomes in many people with cystic fibrosis (pwCF). The relationship between measures of CFTR function, such as sweat chloride concentration, and clinical outcomes in pwCF treated with CFTR modulators is poorly defined. We conducted analyses to better understand the relationships between sweat chloride and CFTR function in vitro, and between sweat chloride and clinical outcomes following CFTR modulator treatment.
View Article and Find Full Text PDFPerennial disaster patterns in Central Europe since 2000 and implications for hospital preparedness planning - a cross-sectional analysis.
Sci Rep
January 2025
Heidelberg University, Medical Faculty Heidelberg, Center for Pediatrics and Adolescent Medicine, Pediatric Neurology and Metabolic Medicine, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.
The goal of this analysis is to describe seasonal disaster patterns in Central Europe in order to raise awareness and improve hospital disaster planning and resilience, particularly during peak events. Hospitals are essential pillars of a country's critical infrastructure, vital for sustaining healthcare services and supporting public well-being-a key issue of national security. Disaster planning for hospitals is crucial to ensure their functionality under special circumstances.
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