AI Article Synopsis
- The study investigated the effects of the drug MPG on the preservation and storage of human platelets for transfusions by assessing its role in inhibiting platelet aggregation.
- The research involved both in vitro experiments, which measured platelet characteristics after being resuspended in fresh plasma, and in vivo experiments, where stored platelets were labeled and retransfused to see how they performed.
- Results were compared between platelets preserved with MPG and control platelets without the drug to evaluate MPG's effectiveness as a cytoprotective agent.
Article Abstract
The SH group containing drug MPG which inhibits platelet aggregation in a reversible manner was used as a cytoprotective substance in some experiments on preparation and storage of human platelets for transfusion. In vitro (n = 6): concentration, morphology score, HSR and aggregation of stored platelets were measured after simulating in vitro the post transfusional conditions by resuspension of stored platelets in fresh drawn plasma (pH 7.4, 37 degrees C). In vivo (n = 2): Autologous platelets stored for 48 h at 22 degrees C were labelled with 111In and retransfused. The results obtained from platelets prepared and stored in plasma containing MPG were compared with those obtained from control platelets without MPG.
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