AI Article Synopsis
- The study aims to assess the effectiveness of concurrent chemoradiotherapy (CCRT) in improving survival and larynx preservation in patients with advanced resectable squamous cell carcinoma of the hypopharynx.
- A total of 102 patient records were analyzed, comparing outcomes based on high-dose versus low-dose chemotherapy regimens alongside radiotherapy.
- Results showed a 5-year overall survival rate of 51.3% and identified chemotherapy content and N stage as key factors influencing overall survival and disease-specific survival.
Article Abstract
Purpose: The purpose of the study is to review our experience with concurrent chemoradiotherapy (CCRT) for patients with advanced resectable squamous cell carcinoma(SCC) of the hypopharynx and to evaluate the factors affecting survival and larynx preservation.
Study Design: Retrospective study.
Methods And Materials: T he records of 102 patients with Stage III or IV resectable SCC of the hypopharynx treated with CCRT between January 1998 and August 2010 were reviewed. Of the 102 patients, 62 were treated with high dose regimens including cisplatin, 5-fluorouracil, methotrexate, leucovorin or docetaxel, cisplatin, and 5-fluorouracil. The remaining 40 were treated with low-dose regimens including carboplatin and uracil-tegafur, weekly docetaxel, or S-1. Radiotherapy was delivered 5 days a week using a single daily fraction of 1.8–2.0 Gray (Gy), to a total dose of 64.8–70.2 Gy. Overall survival (OS), disease-specific survival (DSS), and DSS with larynx preservation were estimated using Kaplan–Meier methods. The log-rank test and Cox proportional hazards regression were used to identify significant prognostic factors for OS, DSS, and DSS with larynx preservation.
Results: The 5-year OS and DSS for all patients treated with CCRT were 51.3 and 64.3 %, respectively. The 5-year DSS with larynx preservation was 55.5 %. On multivariate analysis, the content of chemotherapy was a significant predictor of OS and DSS for patients undergoing CCRT ; N stage was a significant prognostic factor for DSS and larynx preservation.
Conclusion: T he treatment method including the indication for CCRT may be determined by the contents of the chemotherapy and the N stages of SCC of the hypopharynx.
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| http://dx.doi.org/10.1007/s00280-014-2448-2 | DOI Listing |
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