A new bump in the epigenetic landscape.

Mol Cell

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. Electronic address:

Published: March 2014

In this issue of Molecular Cell, Cheng et al. describe an unexpected role for the histone methyltransferases MLL3 and MLL4 in the repression of tissue-specific promoters, a function that prevents precocious cell differentiation in the skeletal muscle lineage.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058326PMC
http://dx.doi.org/10.1016/j.molcel.2014.03.001DOI Listing

Publication Analysis

Top Keywords

bump epigenetic
4
epigenetic landscape
4
landscape issue
4
issue molecular
4
molecular cell
4
cell cheng
4
cheng et al
4
et al describe
4
describe unexpected
4
unexpected role
4

Similar Publications

Background: Diabetes in pregnancy is associated with increased risk of long-term metabolic disease in the offspring, potentially mediated by in utero epigenetic variation. Previously, we identified multiple differentially methylated single CpG sites in offspring of women with gestational diabetes mellitus (GDM), but whether stretches of differentially methylated regions (DMRs) can also be identified in adolescent GDM offspring is unknown. Here, we investigate which DNA regions in adolescent offspring are differentially methylated in blood by exposure to diabetes in pregnancy.

View Article and Find Full Text PDF

Genome-wide DNA methylation analysis in female veterans with military sexual trauma and comorbid PTSD/MDD.

J Affect Disord

April 2024

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA; Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address:

Article Synopsis
  • Military sexual trauma (MST) is a significant concern in the U.S. military, often leading to mental health issues like PTSD and major depressive disorder, but not all MST victims experience these conditions.
  • In this study, saliva samples from 113 female veterans were analyzed for DNA methylation patterns to understand differences between those with and without MST, PTSD, and major depressive disorder.
  • The research identified a specific region near the ZFP57 gene that showed altered DNA methylation in PTSD cases, suggesting that ZFP57 may play a role in PTSD susceptibility and warranting further investigation.
View Article and Find Full Text PDF

Bioorthogonal Chemical Epigenetic Modifiers Enable Dose-Dependent CRISPR Targeted Gene Activation in Mammalian Cells.

ACS Synth Biol

April 2022

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.

CRISPR-Cas9 systems have been developed to regulate gene expression by using either fusions to epigenetic regulators or, more recently, through the use of chemically mediated strategies. These approaches have armed researchers with new tools to examine the function of proteins by intricately controlling expression levels of specific genes. Here we present a CRISPR-based chemical approach that uses a new chemical epigenetic modifier (CEM) to hone to a gene targeted with a catalytically inactive Cas9 (dCas9) bridged to an FK506-binding protein (FKBP) in mammalian cells.

View Article and Find Full Text PDF

DNA methylation alterations in muscle of critically ill patients.

J Cachexia Sarcopenia Muscle

June 2022

Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.

Background: Intensive care unit (ICU)-acquired weakness can persist beyond ICU stay and has been associated with long-term functional impairment of ICU survivors. Recently, DNA methylation alterations were found in the blood of ICU patients, partially explaining long-term developmental impairment of critically ill children. As illness-induced aberrant DNA methylation theoretically could also be involved in long-term weakness, we investigated whether the DNA methylation signature in muscle of adult critically ill patients differs from that in muscle of healthy controls.

View Article and Find Full Text PDF

The fundamental repeating unit of chromatin, the nucleosome, is composed of DNA wrapped around two copies each of four canonical histone proteins. Nucleosomes possess 2-fold pseudo-symmetry that is subject to disruption in cellular contexts. For example, the post-translational modification (PTM) of histones plays an essential role in epigenetic regulation, and the introduction of a PTM on only one of the two "sister" histone copies in a given nucleosome eliminates the inherent symmetry of the complex.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!