The effect of low-molecular dextran given on 6 days after cerebral infarction onset on the content of inorganic phosphorus and lipid-bound phosphorus was studied in 22 patients. The obtained results were compared with those in a control group. Low-molecular dextran caused a statistically significant decrease of the serum lipid-bound phosphorus level in healthy subjects and in patients, which was most pronounced on the sixth day of successive dextran administration, while it had no effect on serum inorganic phosphorus in the studied subjects.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Characterization of oligosaccharides produced by a truncated dextransucrase from Weissella confusa Wcp3a isolated from pozol, a traditional fermented corn beverage.
Int J Biol Macromol
January 2025
Departamento de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología, UNAM, Av. Universidad, 2001, Chamilpa, Cuernavaca, Mor., Mexico. Electronic address:
Glucansucrase Dsr_Wcp3a from a Weissella confusa strain discovered in fermented maize (pozol) was produced in E. coli BL21 resulting in three truncated forms of the native enzyme. An important modification of specificity is observed, as the truncated enzymes synthesize low molecular weight dextran from sucrose, probably due to the absence of domains IV and V, compared to the native enzyme which produces high molecular weight dextran.
View Article and Find Full Text PDFOptimizing Drug Delivery to the Brain for Breast Metastasis: A Novel Method for Tumor Targeting.
Cureus
November 2024
Radiology, Wayne State University, Detroit, USA.
Introduction: Brain metastases are difficult to treat due to the blood-brain barrier limiting the delivery of therapeutic agents to the brain effectively. Intraventricular drug delivery has not been well studied for intra-axial pathologies. However, our prior work demonstrated that intraventricular drug delivery in a hyperosmolar vehicle showed preferential accumulation of drug within breast cancer tissue compared to surrounding brain parenchyma.
View Article and Find Full Text PDFKinetic and Mechanistic Release Studies on Hyaluronan Hydrogels for Their Potential Use as a pH-Responsive Drug Delivery Device.
Gels
November 2024
Department of Cellular Biophysics, Max Planck Institute for Medical Research, 69120 Heidelberg, Germany.
Hyaluronic acid, a biocompatible polymer, holds significant potential for drug delivery applications. Its variable degree of protonation, which entails tunable physical properties, makes it an ideal candidate for developing pH-sensitive hydrogels. Like other smart drug delivery systems, pH-responsive hydrogels can enhance medical treatment and expedite the healing process.
View Article and Find Full Text PDFSchiff-Base Cross-Linked Hydrogels Based on Properly Synthesized Poly(ether urethane)s as Potential Drug Delivery Vehicles in the Biomedical Field: Design and Characterization.
ACS Omega
November 2024
Department of Mechanical and Aerospace Engineering, Politecnico di Torino, 10129 Turin, Italy.
-forming hydrogels based on the Schiff-base chemistry are promising for drug delivery applications, thanks to their stability under physiological conditions, injectability, self-healing properties, and pH-responsiveness. In this work, two water-soluble poly(ethylene glycol)-based poly(ether urethane)s (PEUs) were engineered. A high-molecular-weight PEU (SHE3350, 24 kDa, 1.
View Article and Find Full Text PDFAlbumin binding domain fusion improved the therapeutic efficacy of Inhibitor of Differentiation-2 protein in colitis mice.
Life Sci
December 2024
College of Biological and Chemical Engineering, Changsha University, Changsha 410022, Hunan, China. Electronic address:
Aims: The human Inhibitor of Differentiation-2 (hID2) protein is a promising candidate for the treatment of colitis. However, its relatively low molecular weight limits its clinical application. To extend the therapeutic half-life, an albumin-binding domain (ABD), known for its high affinity for human serum albumin (HSA), was fused to hID2, resulting in a recombinant ABD-hID2.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!