Influence of piroxicam on the contractile response of the isolated rat uterus to prostaglandin E1(PGE1) was studied. Piroxicam and isobutylmethylxanthine (IBMX) reduced contractions of the isolated rat uterus induced by PGE1 and decreased the contraction/relaxation velocity ratio. The results suggest that piroxicam might antagonize PGE1 effects on the isolated rat uterus by enhancing relaxation via the cyclic AMP system.
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