Augmentation of Venlafaxine with Aripiprazole in a Case of Treatment-resistant Excoriation Disorder.

Innov Clin Neurosci

Mr. Turner is a third year medical student, Ms. Sutton is a fourth year medical student, and Dr. Sharma is Associate Professor of Consult/Liaison Psychiatry; all from University of Nebraska Medical Center, Psychiatry Department, Omaha, Nebraska.

Published: January 2014

AI Article Synopsis

  • - A 21-year-old woman with excoriation disorder exhibited severe skin lesions and was resistant to typical treatments, with her condition linked to anxiety from her medical stay.
  • - Combining aripiprazole, an antipsychotic, with venlafaxine, an antidepressant she's already taking, led to the resolution of her skin picking behavior.
  • - The case suggests that this medication combination could be a potential option for treatment-resistant excoriation disorder, and further large-scale studies are recommended to explore this approach.

Article Abstract

We present a case of a 21-year-old woman with excoriation disorder that was resistant to currently reported treatment options. Severe lesions were present on multiple sites of her body. The skin picking appeared to be associated with anxiety surrounding her current medical stay and medical condition. The addition of aripiprazole to the venlafaxine she was already taking resulted in resolution of her unconscious picking. This medication combination may be considered by clinicians in the future for treatment-resistant excoriation disorder as its side effect profile is favorable for patients who have failed first-line treatment options. Large-scale studies investigating the use of second generation antipsychotics combined with selective serotonin reuptake inhibitors/serotonin norepinephrine reuptake inhibitors for the treatment of excoriation disorder is recommended.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960782PMC

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