AI Article Synopsis
- The study aimed to evaluate how the positioning of a set point (T1) influences metrics obtained from computed tomographic perfusion (CTp) imaging in patients with liver tumors.
- The analysis involved 16 patients, using a mix of modeling techniques to compare blood flow, volume, and other metrics at different T1 time intervals.
- The results showed that while blood flow was stable, significant changes in other CTp parameters occurred with T1 shifts of +1.0 seconds or -2.0 seconds or more, indicating that T1 positioning critically impacts these measurements.
Article Abstract
Objective: The objective of this study was to assess the effects of pre-enhancement set point (T1) positioning on computed tomographic perfusion (CTp) parameter values.
Methods: The CTp data from 16 patients with neuroendocrine liver metastases were analyzed with distributed parameter modeling to yield tissue blood flow (BF), blood volume, mean transit time, permeability, and hepatic arterial fraction for tumor and normal liver, with displacements in T1 of ±0.5, ±1.0, ±2.0 seconds, relative to the reference standard. A linear mixed-effects model was used to assess the displacement effects.
Results: Effects on the CTp parameter values were variable: BF was not significantly affected, but T1 positions of ≥+1.0 second and -2.0 seconds or longer significantly affected the other CTp parameters (P ≤ 0.004). Mean differences in the CTp parameter values versus the reference standard for BF, blood volume, mean transit time, permeability, and hepatic arterial fraction ranged from -5.0% to 5.2%, -12.7% to 8.9%, -12.5% to 8.1%, -5.3% to 5.7%, and -12.9% to 26.0%, respectively.
Conclusions: CTp parameter values can be significantly affected by T1 positioning.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101020 | PMC |
| http://dx.doi.org/10.1097/RCT.0000000000000053 | DOI Listing |
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