AI Article Synopsis
- The study examined how keratin proteins change during tumor progression in the hamster cheek pouch, using DMBA as a carcinogen.
- It found a notable decrease in 67 K keratins and an increase in 46 K keratins in hyperplastic and well-developed tumors compared to control samples.
- The findings indicate a connection between low molecular weight keratins, increased tonofilament bundles, and the undifferentiated characteristic of oral tumors.
Article Abstract
The altered pattern in the expression of keratin proteins as a function of tumour progression was studied in the hamster cheek pouch and compared the changes with electron microscopic observations using DMBA as a carcinogen. In the case of hyperplasia and well developed tumours a conspicuous loss of 67 K and an increase in 46 K was observed compared to the controls. The increased expression of low molecular weight keratins during tumour growth is well supported by the enhanced expression of tonofilament bundles, electron microscopically. This study suggests a triangular relationship between the presence of low molecular weight keratins-enhanced expression of tonofilament bundles and the undifferentiated nature of the oral tumours.
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| http://dx.doi.org/10.1016/0309-1651(88)90031-8 | DOI Listing |
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