Hearing damage and deafness: a role for the circadian clock.

Curr Biol

Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK. Electronic address:

Published: March 2014

Severe noise can cause permanent hearing damage. A recent study now shows that the capacity to recover from noise damage varies with time of day, driven by circadian clock control of a nerve growth factor (BDNF) in the inner ear.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cub.2014.01.054DOI Listing

Publication Analysis

Top Keywords

hearing damage
8
circadian clock
8
damage deafness
4
deafness role
4
role circadian
4
clock severe
4
severe noise
4
noise permanent
4
permanent hearing
4
damage study
4

Similar Publications

Hearing loss is one of the most common sensory disorders in humans, and a large number of cases are due to ear cell damage caused by ototoxic drugs including anticancer agents, such as cisplatin. The recent literature reported that hearing loss is promoted by an excessive generation of reactive oxygen species (ROS) in cochlea cells, which causes oxidative stress. Recently, polysaccharides from the cyanobacterium showed many biological activities, including antioxidant activity, suggesting their potential use to combat hearing loss.

View Article and Find Full Text PDF

Knockout of Causes Inner Ear Developmental Defects in Zebrafish.

Biomedicines

December 2024

Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan 430074, China.

: Alternative splicing is essential for the physiological and pathological development of the inner ear. Disruptions in this process can result in both syndromic and non-syndromic forms of hearing loss. DHX38, a DEAH box RNA helicase, is integral to pre-mRNA splicing regulation and plays critical roles in development, cell differentiation, and stem cell maintenance.

View Article and Find Full Text PDF

Phantom perceptions like tinnitus occur without any identifiable environmental or bodily source. The mechanisms and key drivers behind tinnitus are poorly understood. The dominant framework, suggesting that tinnitus results from neural hyperactivity in the auditory pathway following hearing damage, has been difficult to investigate in humans and has reached explanatory limits.

View Article and Find Full Text PDF

The sense of hearing originates in the cochlea, which detects sounds across dynamic sensory environments. Like other peripheral organs, the cochlea is subjected to environmental insults, including loud, damage-inducing sounds. In response to internal and external stimuli, the central nervous system directly modulates cochlear function through olivocochlear neurons (OCNs), which are located in the brainstem and innervate the cochlear sensory epithelium.

View Article and Find Full Text PDF

Cochlear implants are well established devices for treating severe hearing loss. However, due to the trauma caused by the insertion of the electrode and the subsequent formation of connective tissue, their clinical effectiveness varies. The aim of the current study was to achieve a long-term reduction in connective tissue growth and impedance by combining surface patterns on the electrode array with a poly-L-lactide coating containing 20% diclofenac.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!