AI Article Synopsis
- The study explored the use of miR-124-3p and miR-16 plasma levels as diagnostic tools for acute stroke.
- Results showed that miR-124-3p levels were higher in hemorrhagic stroke patients, while miR-16 levels were elevated in ischemic stroke patients.
- Both markers effectively distinguished between the two types of stroke, with miR-16 showing a stronger discriminatory odds ratio.
Article Abstract
Background: The present study aimed to investigate and compare plasma concentrations of miR-124-3p and miR-16 as diagnostic markers in acute stroke.
Methods: miR-124-3p and miR-16 concentrations in 93 stroke patients were analyzed using real-time polymerase chain reaction. The primary outcome was the differentiation of hemorrhagic and ischemic stroke.
Results: Of 93 patients, 74 (79.6%) were diagnosed as ischemic stroke (IS) and 19 (20.4%) were diagnosed as hemorrhagic stroke (HS). Median plasma 124-3p concentrations taken within 24h of symptom onset were higher in HS patients than that in IS patients (3.8×10(5) vs 2.0×10(5) copies/ml plasma, p=0.0109), while median miR-16 concentration in IS patients were higher than that in HS patients (1.6×10(9) vs 1.3×10(9) copies/ml plasma, p=0.0399). The odds ratio (OR) for discriminating HS and IS with miR-124-3p and miR-16 was 5.37 and 9.75 respectively.
Conclusion: Both miR-124-3p and miR-16 are diagnostic markers to discriminate HS and IS.
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| http://dx.doi.org/10.1016/j.cca.2014.03.007 | DOI Listing |
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