Background: The high prevalence of allergic rhinitis (AR) leads to high morbidity and costs. Specific immunotherapy (SIT) is a potentially curative therapy for AR. The -decision whether or not to employ SIT is often not totally clear.
Patients And Methods: In 2012/13, as part of company skin cancer screening -programs, employed persons between the ages of 16-70 were asked about use of allergy-related medications and atopic conditions, as well as the use of SIT or possible reasons preventing its use.
Results: Of the 15,164 persons surveyed, 26.2% (n = 3,966) reported they had allergies that might benefit from SIT therapy. Of these, only 31.7% (n = 1,470) had undergone SIT therapy, with 63.3% (n = 931) describing the treatment as successful. The main reasons given for not undergoing SIT were relatively minor symptoms (51.2%; n = 1,278), little confidence in the success of therapy, and lack of time (12%; n = 300). Only 5.2%, n = 129) stated that avoiding allergens was sufficient or that they could not undergo SIT because of other health problems. Another 5.2% (n = 130) said they had either not heard of SIT, or had not found a place to undergo treatment.
Conclusions: Although about one-quarter of respondents reported allergies that might benefit from SIT, less than one-third had undergone treatment. The main -reason was having mild symptoms; guideline or healthcare-related issues were -responsible only to a limited extent.
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http://dx.doi.org/10.1111/ddg.12298 | DOI Listing |
Alzheimers Dement
December 2024
Brigham and Women's Hospital and Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
The most recent Alzheimer's clinical trials, including those which reported successful outcomes, use neuroimaging biomarkers of both amyloid and tau for screening participants and demonstrating a treatment effect on pathology. Some of these trials, notably Lecanemab, hint at a potential sex bias in treatment outcome, alluding to major implications for clinical practice when recommending treatment options. Sex differences in treatment response are not surprising given that women are at greater risk of progression to AD dementia, particularly if they carry APOEe4.
View Article and Find Full Text PDFJ Neuroeng Rehabil
January 2025
Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China.
Background: Motion complexity is necessary for adapting to external changes, but little is known about trunk motion complexity during seated perturbation in individuals with spinal cord injury (SCI). We aimed to investigate changes following SCI in trunk segmental motion complexity across different perturbation directions and how they affect postural control ability in individuals with SCI.
Methods: A total of 17 individuals with SCI and 18 healthy controls participated in challenging sagittal-seated perturbations with hand protection.
BMC Musculoskelet Disord
January 2025
Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Marmara University, İstanbul, Turkey.
Background: No other study has addressed the effectiveness of dual-task training in the postoperative period of total hip arthroplasty (THA). This study investigated the efficacy of dual-task training in older adults with THA.
Methods: Patients were randomized into the control group (CG) (n = 14) and intervention group (IG) (n = 14).
Food Res Int
January 2025
School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai 201418, China. Electronic address:
The interaction between proteins and aroma compounds significantly impacts cheese flavor retention during processing. However, it is still unknown how cheese proteins and the aldehyde aroma compounds (AACs) interact. This study aims to clarify the interaction mechanisms between the AACs (benzaldehyde, 2-methylpropanal, 2-methylbutanal and 3-methylbutanal) and β-casein (β-CN) using SPME-GC/MS, multi-spectroscopy techniques, and molecular dynamics simulations.
View Article and Find Full Text PDFFood Res Int
January 2025
School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai 201418, China. Electronic address:
The study investigated the perceptual interaction between two types of Rose damascena essential oil and two types of Angelica dahurica root essential oil. Using gas chromatography-olfactometer (GC-O) and gas chromatography-mass spectrometer (GC-MS), 24 and 25 aromatic compounds in Rose damascena essential oil and Angelica dahurica root essential oil were identified and quantified, respectively. Based on flavor dilution (FD) values and odor activity values (OAVs), 10 important aroma compounds in Rose damascena essential oil and 6 in Angelica dahurica root essential oil were identified.
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