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Novel therapeutic approaches targeting cancer stem cells: Unveiling new frontiers in breast cancer treatment.
Pathol Res Pract
December 2024
Department of Zoology (PG), Vellalar College for Women, Erode, India. Electronic address:
Breast cancer remains the leading cause of mortality among women with cancer. This article delves into the intricate relationship between breast cancer and cancer stem cells (CSCs), emphasizing advanced methods for their identification and isolation. The key isolation techniques, such as the mammosphere formation assay, surface marker identification, Side Population assay, and Aldehyde Dehydrogenase assay, are critically examined.
View Article and Find Full Text PDFEffect of Fitness Level on Time Course of Recovery After Acute Strength and High-Intensity Interval Training.
J Strength Cond Res
December 2024
School of Medical and Health Sciences, Edith Cowan University, Joondalup, Australia.
Grammenou, M, Kendall, KL, Wilson, CJ, Porter, T, Laws, SM, and Haff, GG. Effect of fitness level on time course of recovery after acute strength and high-intensity interval training. J Strength Cond Res 38(12): 2055-2064, 2024-The aim was to investigate time course of recovery after acute bouts of strength (STR) and high-intensity interval training (HIIT).
View Article and Find Full Text PDFValue Cocreation and Codestruction in Digital Health Services: Protocol for a Systematic Review.
JMIR Res Protoc
January 2025
Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Background: To successfully design, develop, implement, and deliver digital health services that provide value, they should be cocreated with patients. However, occasionally, the value may also be codestructed. In the field of health care, the concepts of value cocreation and codestruction still need to be better established within emerging digital health services.
View Article and Find Full Text PDFProgram Director and Nephrology Fellow Perception of Home Hemodialysis Education in the United States.
Kidney360
November 2024
Nephrology Service, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, MD.
Background: Public policy focuses on increasing the prevalence of home dialysis. Home hemodialysis (HHD) education and comfort with the procedure are significant barriers to increasing prevalence. This study examines nephrology fellowship didactic curriculum, training program infrastructure and barriers identified by both program directors and trainees.
View Article and Find Full Text PDFAccelerating the Future of Oncology Drug Development: The Role of Consortia in the Delivery of Precision Oncology Early Phase Clinical Trials.
J Clin Oncol
January 2025
The Kinghorn Cancer Centre, St Vincent's Hospital, Sydney, NSW, Australia.
Purpose: Over the past 15 years, the landscape of early phase clinical trials (EPCTs) has undergone a remarkable expansion in both quantity and intricacy. The proliferation of sites, trials, sponsors, and contract research organizations has surged exponentially, marking a significant shift in research conduct. However, EPCT operations suffer from numerous inefficiencies, such as cumbersome start-up processes, which are particularly critical when drug safety and the recommended phase II dose need to be established in a timely manner.
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