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Thyroid Hormone and Diabetes Mellitus Interplay: Making Management of Comorbid Disorders Complicated.
Horm Metab Res
December 2024
Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, India.
Insulin and thyroid hormones play important roles in our body. Insulin helps regulate the glucose level while the thyroid hormones affect various cells and tissues, metabolizing protein, lipids, and glucose. Hyperthyroidism and thyrotoxicosis are potential hazards for type 2 diabetes mellitus.
View Article and Find Full Text PDFScreening of Individuals with Type 2 Diabetes on Anti-Diabetic Agents for Probable Hypoglycaemia Using the Stanford Hypoglycemia Questionnaire (SHQ) in Outpatient Settings: A Cross-Sectional Study from Outpatient Diabetes Care Centres in North India.
Indian J Endocrinol Metab
February 2024
Internal Medicine, Harsh Clinic and Diabetes Care Centre, Lucknow, Uttar Pradesh, India.
Introduction: The study was aimed at identifying the incidence of unreported probable hypoglycaemia in individuals with type 2 diabetes (T2DM) on anti-diabetic medications, using the screening Stanford Hypoglycemia Questionnaire (SHQ) in real-world situations.
Methods: It was a multicentre cross-sectional study on consecutive individuals attending 10 diabetes care centres in Lucknow, Uttar Pradesh, India. The inclusion criteria were as follows: known individuals with T2DM, literate, age greater than or equal to 18 years, on at least one anti-diabetic agent for more than a month and not engaged in regular self-monitoring of blood glucose (SMBG).
Pioglitazone ameliorates doxorubicin-induced hypothyroidism and cardiotoxicity in rat models.
Eur Rev Med Pharmacol Sci
October 2023
Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah, Al Qassim, Saudi Arabia.
Unlabelled: OBJECTIVE: The anticancer drug doxorubicin (DOX) is effective but is associated with complications such as hypothyroidism and cardiotoxicity. Pioglitazone (PIO), which is used to treat diabetes mellitus, has shown potential for treating hypothyroidism and cardiac dysfunction. Therefore, this study explores whether PIO can also ameliorate DOX-induced hypothyroidism and cardiotoxicity.
View Article and Find Full Text PDFEffects of enteral nutrition supplemented with octanoic acid on lipopolysaccharide-induced intestinal injury: role of peroxisome proliferator-activated receptor γ/STAT-1/myeloid differentiation factor 88 pathway.
Nutrition
December 2023
Department of General Surgery, Second Affiliated Hospital of Soochow University, Suzhou, China. Electronic address:
Objective: Enteral nutrition is the key therapy in septic patients. Different formulas of enteral nutrition have various effects on gastrointestinal sepsis. Therefore, we investigated the effects of enteral nutrition supplemented with octanoic acid on lipopolysaccharide-induced intestinal injury and explored the potential mechanism.
View Article and Find Full Text PDFOctanoic Acid-rich Enteral Nutrition Alleviated Acute Liver Injury Through PPARγ/STAT-1/MyD88 Pathway in Endotoxemic Rats.
In Vivo
June 2023
Department of General Surgery, Second Affiliated Hospital of Soochow University, Suzhou, P.R. China;
Background/aim: Acute liver injury is the hallmark of organ failure in sepsis. Enteral nutrition (EN) is an important clinical therapeutic measure in septic patients. However, the therapeutic effect of EN alone is not obvious.
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