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Horizontal Gaze Tolerance and Its Effects on Visual Sensitivity in Glaucoma.
Invest Ophthalmol Vis Sci
January 2025
Department of Ophthalmology, Saitama Medical University, Saitama, Japan.
Purpose: This study evaluates the effect of 6° horizontal gaze tolerance on visual field mean sensitivity (MS) in patients with glaucoma using a binocular head-mounted automated perimeter, following findings of structural changes in the posterior globe from magnetic resonance imaging and optical coherence tomography.
Methods: In this cross-sectional study, a total of 161 eyes (85 primary open-angle glaucoma [POAG] and 76 healthy) from 117 participants were included. Logistic regression and 1:1 matched analysis assessed the propensity score for glaucoma and healthy eyes, considering age, sex, and axial length as confounders.
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive impairments in episodic and spatial memory, as well as circuit and network-level dysfunction. While functional impairments in medial entorhinal cortex (MEC) and hippocampus (HPC) have been observed in patients and rodent models of AD, it remains unclear how communication between these regions breaks down in disease, and what specific physiological changes are associated with the onset of memory impairment. We used silicon probes to simultaneously record neural activity in MEC and hippocampus before or after the onset of spatial memory impairment in the 3xTg mouse model of AD pathology.
View Article and Find Full Text PDFPartial directed coherence analysis of resting-state EEG signals for alcohol use disorder detection using machine learning.
Front Neurosci
January 2025
Center of Excellence in Intelligent Engineering Systems (CEIES), Department of Electrical and Computer Engineering, Faculty of Engineering, King Abdulaziz University, Jeddah, Saudi Arabia.
Introduction: Excessive alcohol consumption negatively impacts physical and psychiatric health, lifestyle, and societal interactions. Chronic alcohol abuse alters brain structure, leading to alcohol use disorder (AUD), a condition requiring early diagnosis for effective management. Current diagnostic methods, primarily reliant on subjective questionnaires, could benefit from objective measures.
View Article and Find Full Text PDFThe competition for resources is a defining feature of microbial communities. In many contexts, from soils to host-associated communities, highly diverse microbes are organized into metabolic groups or guilds with similar resource preferences. The resource preferences of individual taxa that give rise to these guilds are critical for understanding fluxes of resources through the community and the structure of diversity in the system.
View Article and Find Full Text PDFMulti-decadal tree-ring stable isotope records of apple and pear trees indicate coherent ecophysiological responses to environmental changes in alpine valleys.
Front Plant Sci
January 2025
Faculty of Agricultural, Environmental and Food Sciences, Free University of Bolzano, Bolzano, Italy.
The ecophysiological and ecohydrological impacts of climate change and progressively increasing atmospheric carbon dioxide (CO) concentration on agroecosystems are not well understood compared to the forest ecosystems. In this study, we utilized the presence of old apple and pear trees in the alpine valleys of Northern Italy (maintained for cultural heritage purposes) to investigate climate-scale physiological responses. We developed long-term tree-ring stable isotopic records (δC and δO) from apple (1976-2021) and pear trees (1943-2021).
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