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In two models of depression-like state--"behavioral despair" and experimental dopamine deficit-dependent MPTP-induced depression-like syndrome--as well as in a model of anxiety-depression-like state induced by dipeptidyl peptidase IV inhibitor methionyl-2(s)-cyanopyrrolidine administered in early postnatal period, the symptoms of behavioral depression in rats in the forced swim test were accompanied by the increase of corticosterone level in blood serum. In every model non-competitive prolyl endopeptidase (PEP) inhibitor benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine showed antidepressant-like properties preventing the development of depressive-like behavior. PEP Inhibitor also prevented the increase of serum corticosterone level in the models of "behavioral despair" and anxiety-depressive state, but not in the model of MPTP-induced depression-like syndrome. These findings testify for the involvement of hypothalamic-pituitary-adrenal system in the implementation of depression-like behavior in the specified models of depression-like state.
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Poult Sci
March 2025
MOE Joint International Research Laboratory of Animal Health & Food Safety, Nanjing Agricultural University, Nanjing, Jiangsu, 210095, PR China; Key Laboratory of Animal Physiology & Biochemistry, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, 210095, PR China. Electronic address:
Avian pathogenic Escherichia coli (APEC) infection has high morbidity and mortality, and multiple stressors encountered during rearing place poultry in a state of stress. However, research on how poultry cope with APEC infection under stress situation is still limited. In this study, we established a broiler stress model by corticosterone (CORT) administration subcutaneously for 7 consecutive days, followed by APEC challenge intramuscularly.
View Article and Find Full Text PDFFront Pharmacol
February 2025
School of Biological Sciences and Engineering, Shaanxi University of Technology, Hanzhong, China.
Anxiety disorders and depression often co-occur and lack broadly available treatments. Gardenia extract significantly associated with treatment of anxiety-like depression. Based on the dose effect hypothesis and previous studies, it is speculated that crocin I, the main component of gardenia, is significantly related to the treatment of anxiety-like depression.
View Article and Find Full Text PDFNutrients
March 2025
College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea.
Chronic stress disrupts neurochemical balance, triggers inflammation, and compromises neuronal integrity, contributing to the development of stress-related disorders. This study aimed to evaluate the preventative effects of Berk (TF) enzymatic extracts on chronic restraint stress (CRS)-induced behavioral, neurochemical, and inflammatory dysfunctions in mice. Male C57BL/6N mice were administered TF at doses of 50 mg/kg and 100 mg/kg daily via oral gavage for 21 days during CRS exposure.
View Article and Find Full Text PDFPharmacol Biochem Behav
March 2025
School of Biology, Damghan University, Damghan, Iran. Electronic address:
Chronic stress (Ch.S) has detrimental effects on the brain's structure and function, particularly in the hippocampus. The noradrenergic and orexinergic systems play crucial roles in the stress response and regulation of stress-related behaviors.
View Article and Find Full Text PDFBMC Zool
March 2025
Laboratorio de Zoología Terrestre, Instituto de Biodiversidad Tropical IBIOTROP, Colegio de Ciencias Biológicas y Ambientales, Universidad San Francisco de Quito USFQ, Quito, 170901, Ecuador.
Land use changes can have morphological and physiological impacts on wildlife. This study aimed to explore the influence of anthropogenic land use on the morphology and corticosterone concentrations in two songbirds endemic to the Galapagos archipelago: the granivorous Small Ground Finch Geospiza fuliginosa and the insectivorous Galapagos Yellow Warbler Setophaga petechia aureola in San Cristobal Island. Birds were caught and measured between June and August 2018 and June and July 2019 across four areas with different human land uses: urban green areas in the coastal town of Puerto Baquerizo Moreno, natural deciduous forest in the lowlands, agricultural areas in the highlands, and seasonal evergreen forest in the highlands.
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