[Relationships between serum lipid composition and acetylator status as markers of energy metabolism in women with coronary heart disease, metabolic syndrome, and type 2 diabetes mellitus].

Aim: To study relationships between the indicators of serum lipid composition (SLC) and the markers of acetylator (energy) status (AS) in women with coronary heart disease (CHD), stable exertional angina (SEA), metabolic syndrome (MS), type 2 diabetes mellitus (DM) (according to the data multivariate correlation analysis).

Subjects And Methods: One hundred and eight women aged 54.9 +/- 0.7 years with CHD, Functional Class I-III SEA, MS, and type 2 DM were examined. SLC was studied, by determining the levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), high-density lipoprotein cholesterol (HDL-C), atherogenic coefficient (AC), triglyceride coefficient (TC) (TC=TG/HDL-C). AS markers, such as blood acetylation degree (BAD) and the total acetylating capacity of the body (TACB), were concurrently determined. Correlations of each individual indicator of a lipidogram (TC, TG, LDL-C, VLDL-C, HDL-C, AC, and TC) and an AS marker (BAD, TACB) were analyzed in tandem.

Results: Examination of the relationships between SLC the indicators and AS markers in women with CHD, MS, and type 2 DM could establish that the values of a variant, < or = 10th and > 90th percentiles of SLC indicators (TC, TG, LDL-C, VLDL-C, HDL-C, AC, and TC) showed a significant strong direct (positive) relationship to those of the variant, < or =10th and > 90th percentiles of AS markers (BAD, TACB). A significant inverse (negative) correlation was found between the values of the < or = 10th percentile of SLC indicators (TC, TG, LDL-C, VLDL-C, HDL-C, AC, and TC) and those of > 90th percentile of AS markers (BAD, TACB), as well as between the values of >90th percentile of SLC indicators (TC, TG, LDL-C, VLDL-C, HDL-C, AC, and TC) and those of < or = 10th percentile of AS markers (BAD, TACB).

Conclusion: The heterogeneity in the association was ascertained between the values of < or = 10th percentile/> 90th percentile/variant of SLC and AS markers. The genetic polymorphism of AS - the phenotypes of slow/fast/intermediate acetylators (a three modal distribution) was stated. Knowledge of the patterns of relationships between BAD/AS and the polymorphism of the phenotypes of slow/fast/intermediate acetylators may contribute to the formation of differentiated groups at risk for cardiovascular and concomitant diseases and to adequate prevention and treatment.