AI Article Synopsis
- The study presents three cases of patients with spinal intradural metastases treated using stereotactic radiotherapy (SRT) after prior external-beam radiation therapy (EBRT).
- Each patient had different types of spinal metastases, including intramedullary and intradural extramedullary tumors, following previous cancer treatments for lung adenocarcinoma and brain metastases.
- The SRT treatment, delivering 24 to 36 Gy over 5 to 12 sessions, resulted in stable or reduced tumor sizes and improved or stable neurological symptoms, suggesting that SRT is a safe and effective option for managing these types of metastases.
Article Abstract
Results of stereotactic radiotherapy (SRT) for spinal intradural metastases developing inside or adjacent to the previous external-beam radiation therapy (EBRT) field are shown in 3 cases. One case of spinal intramedullary metastasis and two cases of intradural extramedullary metastases were treated using a Novalis shaped-beam SRT. Case 1 developed an intramedullary metastatic tumor in the C1 spinal medulla inside the previous whole brain EBRT field and another lesion adjacent to the field in the C2 spinal medulla. Case 2 developed intradural extramedullary metastasis around C6-8 inside the previous EBRT field for the primary lung adenocarcinoma. Case 3 developed multiple spinal intradural extramedullary metastatic deposits after surgical resection and following whole brain EBRT for brain metastasis. We delivered 24 to 36 Gy in 5 to 12 fractions. The treated tumors were stable or decreased in size until the patients' death from the primary cancer (10, 22, and 5 months). Neurological symptoms were stable or improved in all 3 patients. Palliative SRT using Novalis is expected to be safe and effective even if the patient develops spinal intradural metastases within or adjacent to the previous irradiation field.
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