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The development and implementation of an innovative community-based intervention to strengthen community capacity for HIV prevention and care among Canadians of African Caribbean and Black (ACB) women in Ontario: a research protocol.
Glob Public Health
December 2025
Office of Vice President, Equity, Diversity, Inclusion, University of Windsor (Ontario), Windsor, Canada.
African, Caribbean, and Black (ACB) women are overrepresented among new HIV diagnoses due to social and structural factors. This study seeks to create, implement, and evaluate a community-based peer-led intervention to improve access to HIV prevention and care for ACB women in Canada. This multisite, five-year project, using community-based participatory research, implementation science and evaluation frameworks, will be implemented in five non-iterative phases.
View Article and Find Full Text PDFUnmet Social Needs of Older Adults With Mobility Limitations Following Inpatient Rehabilitation Discharge in Nigeria: A Qualitative Narrative Inquiry Study.
J Geriatr Phys Ther
January 2025
Emerging Researchers & Professionals in Aging-African Network, Nigeria & Canada.
Background And Purpose: Approximately, 30% to 60% of older adults experience functional decline following hospitalization, which has implications for their ability to meet social needs after discharge. Exploring the unmet social needs of older adults following discharge is warranted to rethink the elements of hospital discharge in low-resource countries. This study explored the unmet social needs of older adults with mobility limitations following discharge from an inpatient rehabilitation unit in a state hospital in Northern Nigeria.
View Article and Find Full Text PDFAssessment of Four Essential Features of the Alive & Thrive Initiative to Improve Maternal, Infant, Young Child, and Adolescent Nutrition.
Matern Child Nutr
January 2025
ELEVATE Nutrition, Washington, District of Columbia, USA.
Alive & Thrive has been a major global nutrition initiative that aimed to learn how to improve maternal, infant, young child, and adolescent nutrition and health on a large scale. During 2009-2014, Alive & Thrive developed and implemented interventions to improve infant and young child feeding at scale in three countries. Subsequently, Alive & Thrive expanded its work to more than 15 geographies, including six country-specific and two regional programs, to additionally address maternal and adolescent nutrition while adding agriculture and social protection programs to improve maternal, infant, and young child nutrition.
View Article and Find Full Text PDFInitiation of primary T cell-B cell interactions and extrafollicular antibody responses in an organized microphysiological model of the human lymph node.
bioRxiv
January 2025
Department of Chemistry, 409 McCormick Road, University of Virginia, Charlottesville, VA 22904.
Antibody production is central to protection against new pathogens and cancers, as well as to certain forms of autoimmunity. Antibodies often originate in the lymph node (LN), specifically at the extrafollicular border of B cell follicles, where T and B lymphocytes physically interact to drive B cell maturation into antibody-secreting plasmablasts. In vitro models of this process are sorely needed to predict aspects of the human immune response.
View Article and Find Full Text PDFUnlabelled: Layer 6 corticothalamic (L6CT) neurons project to both cortex and thalamus, inducing multiple effects including the modulation of cortical and thalamic firing, and the emergence of high gamma oscillations in the cortical local field potential (LFP). We hypothesize that the high gamma oscillations driven by L6CT neuron activation are shaped by the dynamic engagement of intracortical and cortico-thalamo-cortical circuits. To test this, we optogenetically activated L6CT neurons in NTSR1-cre mice expressing channelrhodopsin-2 in L6CT neurons.
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