A synthesis of C11-desmethoxy soraphen A is described that proceeds in just 14 steps from readily available starting materials. This natural product analog was identified as a target of interest in a program aimed at identifying novel natural product-inspired inhibitors of acetyl-CoA carboxylase (ACC) as potential anticancer therapeutics. While describing the most efficient synthesis of a soraphen A analog (total syntheses of the natural product have been reported that proceed in 25 to ≥40 linear steps), we also present data supporting the conclusion that C11-heteroatom functionality is a beneficial but unnecessary structural characteristic of soraphen A analogs for inhibiting ACC.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951358 | PMC |
| http://dx.doi.org/10.1021/ml400377p | DOI Listing |
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