Kinetic analysis of ion channel recordings attempts to distinguish the number and lifetimes of channel molecular states. Most kinetic analysis assumes that the lifetime of each state is independent of previous channel history, so that open and closed durations are Markov processes whose probability densities are sums of exponential decays. An alternative approach assumes that channel molecules have many configurtions with widely varying lifetimes. Rates of opening and closing then vary with the time scale of observation, leading to fractal kinetics. We have examined kinetic behavior in two types of channels from human and avian fibroblasts, using a maximum likehood method to test the dependence of rates on observational time scale. For both channels, openings showed mixed fractal and Markov behavior, while closings gave mainly fractal kinetics.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1139/y88-159 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Introduction to Focus Issue: Data-driven models and analysis of complex systems.
Chaos
March 2025
Institute for Complex Systems and Mathematical Biology, University of Aberdeen, King's College, AB24 3UE Aberdeen, United Kingdom.
This Focus Issue highlights recent advances in the study of complex systems, with a particular emphasis on data-driven research. Our editorial explores a diverse array of topics, including financial markets, electricity pricing, power grids, lasers, the Earth's climate, hydrology, neuronal assemblies and the brain, biomedicine, complex networks, real-world hypergraphs, animal behavior, and social media. This diversity underscores the broad applicability of complex systems research.
View Article and Find Full Text PDFAnomalous diffusion in external-force-affected deterministic systems.
Phys Rev E
July 2024
School of Electronic Information, Central South University, Changsha 410083, China.
This study investigates the impact of external forces on the movement of particles, specifically focusing on a type of box piecewise linear map that generates normal diffusion akin to Brownian motion. Through numerical methods, the research delves into the effects of two distinct external forces: linear forces linked to the particle's current position and periodic sinusoidal forces related to time. The results uncover anomalous dynamical behavior characterized by nonlinear growth in the ensemble-averaged mean-squared displacement (EAMSD), aging, and ergodicity breaking.
View Article and Find Full Text PDFTracking and modeling the movement of Queensland fruit flies, Bactrocera tryoni, using harmonic radar in papaya fields.
Sci Rep
July 2024
Department of Chemistry, Eastern Mennonite University, 1200 Park Road, Harrisonburg, VA, 22802, USA.
Determining movement parameters for pest insects such as tephritid fruit flies is critical to developing models which can be used to increase the effectiveness of surveillance and control strategies. In this study, harmonic radar was used to track wild-caught male Queensland fruit flies (Qflies), Bactrocera tryoni, in papaya fields. Experiment 1 continuously tracked single flies which were prodded to induce movement.
View Article and Find Full Text PDFNeuronal Fractal Dynamics.
Adv Neurobiol
March 2024
Department of Urology, Ameos Hospital Alfeld, Alfeld, Germany.
Synapse formation is a unique biological phenomenon. The molecular biological perspective of this phenomenon is different from the fractal geometrical one. However, these perspectives are not mutually exclusive and supplement each other.
View Article and Find Full Text PDFLooking under the lamp-post: quantifying the performance of contact tracing in the United States during the SARS-CoV-2 pandemic.
BMC Public Health
February 2024
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Contact tracing forms a crucial part of the public-health toolbox in mitigating and understanding emergent pathogens and nascent disease outbreaks. Contact tracing in the United States was conducted during the pre-Omicron phase of the ongoing COVID-19 pandemic. This tracing relied on voluntary reporting and responses, often using rapid antigen tests due to lack of accessibility to PCR tests.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!