AI Article Synopsis
- Neurological soft signs are common in schizophrenia but lack clear diagnostic specificity.
- Researchers studied 305 subjects to determine if these signs specifically relate to schizophrenia.
- The study found significant neurological impairment in schizophrenia patients compared to those with bipolar disorder, supporting the use of neurological soft signs as a diagnostic tool.
Article Abstract
Background: Although neurological soft signs have been consistently described in patients with schizophrenia, their diagnostic specificity is not well clarified.
Methods: To test the hypothesis that neurological soft signs are specifically related to schizophrenia, we examined 305 subjects (patients with schizophrenia-spectrum disorder, n=167; patients with bipolar I disorder, n=88; controls, n=50). Neurological soft signs were assessed using the Neurological Evaluation Scale (NES). Multiple logistic regression analysis was used to compute the diagnostic predictive power of neurological soft signs.
Results: Patients in the schizophrenia-spectrum disorder group were found to have significantly greater neurological impairment (NES total score=23.9, standard deviation [SD] 11.2) than those in the bipolar disorder group (NES total score=18.2, SD 7.6; p<0.001). Neurological functioning was closely associated with psychopathology (all p<0.001). The NES total score reliably distinguished patients with schizophrenia spectrum disorders from those with bipolar disorder in 68.7% of the cases (p<0.001). Moreover, a particular set of neurological soft signs showed specificity for the schizophrenia-spectrum disorder diagnostic group.
Conclusions: Our findings suggest that schizophrenia and bipolar disorder can be distinguished in terms of neurological impairment. Furthermore, we recommend the utility of neurological soft signs as a useful, quantifiable, sensitive, and inexpensive tool for the diagnostic work-up of schizophrenia.
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| http://dx.doi.org/10.1097/01.pra.0000445250.20875.0e | DOI Listing |
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