Unlabelled: The study was performed to determine the predictive value of programmed stimulation for identification of pts with ventricular arrhythmias: 75 patients were studied by means of 24-hour ambulatory ECG (24 ECG) and programmed right (in some patients also left) ventricle stimulation at sinus and two or three pacing rates using two (standard) and three extrastimuli or burst stimulation (extensive protocol). Lown classes 0, 1-3 and 4a-4b were observed in 24 ECG in 35, 14, and 26 patients, respectively. In programmed stimulation 1-6 repetitive ventricular responses (RVR) were found in 56 pts, nonsustained ventricular tachycardia in 11 and sustained ventricular tachycardia in 21 pts. High incidence of induced VT was found in pts with complex ventricular arrhythmia in 24 ECG, 81% of this group, in all but six pts only standard protocol was used. The 1-6 RVR were observed in almost 40% of pts without any arrhythmia.
Conclusion: Only VT induction is a useful index for high risk patients.
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http://dx.doi.org/10.1111/j.1540-8159.1988.tb06334.x | DOI Listing |
Adv Sci (Weinh)
January 2025
Institute of Biomechanics and Medical Engineering, Applied Mechanics Laboratory, Department of Engineering Mechanics, School of Aerospace Engineering, Tsinghua University, Beijing, 100084, China.
Focused ultrasound (FUS) has been widely adopted in medical and life science researches. Although various physical and biological effects of FUS have been well-documented, there is still a lack of understanding and direct evidence on the biological mechanism of therapeutic cell ablation caused by high-intensity ultrasound (HIFU) and the subsequent wound healing responses. This study develops an enclosed cell culture device that synergistically combines non-invasive FUS stimulation and real-time, on-the-fly live-cell imaging, providing an in vitro platform to explore short and long-term biological effects of ultrasound.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, China.
Bacterial infection has become the most dangerous factor in tissue repair, which strongly affects the tissue regeneration efficiency and wellness of patients. Piezoelectric materials exhibit the outstanding advantage of producing electrons without external power supply. The ability of electron enrichment and reactive oxygen species generation through noninvasive stimulations enables piezoelectric materials the potential applications of antibacterial.
View Article and Find Full Text PDFSmall
January 2025
School of Science, Shenzhen Key Laboratory of Advanced Functional Carbon Materials Research and Comprehensive Application, Harbin Institute of Technology, Shenzhen, 518055, China.
Antibiotic-resistant bacteria often cause lethal infections in both the surficial and deep organs of humans. Failure of antibiotics in resistant infections leads to more effective alternative therapies, like spatiotemporally controllable piezodynamic therapy (PZDT) with deep penetration. Currently, PZDT demands further investigation for improved treatment outcomes and the corresponding therapeutic mechanisms.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
Department of Colorectal Surgery, Xinhua Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, 200092, China.
Inflammatory bowel disease (IBD) is associated with oxidative stress and redox signaling disruption. It is recently reported that proautophagic autophagy/beclin-1 regulator 1 (AMBRA1) is a positive modulator of the NF-κB pathway that promotes intestinal inflammation. However, its effect on intestinal redox state and whether AMBRA1 is regulated by oxidative stress remain unknown.
View Article and Find Full Text PDFLeadersh Health Serv (Bradf Engl)
February 2025
Department of Applied Computing and IT, Makerere University Business School, Kampala, Uganda.
Purpose: This study aims to examine the association between transformational leadership, employee well-being and job satisfaction, focusing on the mediating role of employee well-being in the association between transformational leadership and job satisfaction.
Design/methodology/approach: Data for this purpose were gathered by the authors through a questionnaire survey, with 180 employees at health center IV hospitals in Uganda serving as the sample. To test the theoretical model, a PROCESS Model Type 4 mediation analysis was performed.
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