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http://dx.doi.org/10.1113/jphysiol.2013.268318 | DOI Listing |
Environ Sci Technol
November 2022
Center for Urban Waters, Tacoma, Washington 98421, United States.
Expert Opin Ther Targets
May 2017
a Department of Biochemistry and Molecular Biology , Wayne State University School of Medicine, Detroit , MI , USA.
Methionine sulfoximine (MSO), a well-characterized inhibitor of glutamine synthetase, displays significant therapeutic benefits in animal models for several human diseases. This amino acid might therefore be a viable candidate for drug development to treat diseases for which there are few effective therapies. Areas covered: We describe the effects of MSO on brain swelling occurring in overt hepatic encephalopathy resulting from liver failure, the effects of MSO on excitotoxic damage involved in amyotrophic lateral sclerosis (ALS) or resulting from stroke, and the effects of MSO on a model for an inflammatory immune response involved in a range of diseases.
View Article and Find Full Text PDFJ Physiol
September 2015
Department of Medicine, Division of Physiology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0623, USA.
Chest
October 2015
Department of International Health, CAPHRI-School of Public Health and Primary Care, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands; Children's and Adolescents' Hospital, University Hospital of Cologne, Cologne, Germany.
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