AI Article Synopsis
- The study aimed to compare autologous fibrin and human amniotic membrane (HAM) as scaffolds for growing conjunctiva cells for transplantation in rabbits with conjunctival defects.
- Eighteen rabbits were divided into three groups: one group received autologous conjunctiva on fibrin, another on HAM, and the third group had no treatment; healing was monitored for six weeks.
- Results showed that the autologous fibrin group had a quicker healing time compared to the other groups, but the differences were not statistically significant; no complications were reported.
Article Abstract
The purpose of this study was to compare the use of autologous fibrin to human amniotic membrane (HAM) as a scaffold in cultivating autologous conjunctiva for transplantation in treatment of conjunctival defect. An experimental study was performed using 18 adult New Zealand white strain rabbits which were divided into 3 groups. Each group consists of 6 rabbits. The conjunctiva on the temporal site was excised to create a conjunctival epithelial defect. The excised area in the Group 1 was transplanted with autologous conjunctiva cultivated on autologous fibrin; Group 2 was transplanted with autologous conjunctiva cultivated on HAM and Group 3 was left bare. The rabbits were followed up at regular intervals until 6 weeks. The mean period of complete conjunctival epithelization was 11.50 ± 8.22 days for the autologous fibrin group, 15.33 ± 11.80 days for the HAM group and 25.33 ± 5.32 days in the bare sclera group. The epithelization rate for the autologous fibrin group was faster compared to the other two groups. However all the results were not statistically significant (p value >0.05). There were no postoperative complications noted during the follow up. Autologous fibrin is comparable to HAM as a scaffold for cultivation of conjunctiva in the treatment of conjunctival defect.
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| http://dx.doi.org/10.1007/s10561-014-9436-y | DOI Listing |
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