Unspliced Rous sarcoma virus (RSV) retroviral mRNA undergoes nonsense-mediated RNA decay (NMD) if it has premature termination codons in the gag gene. However, its normal gag termination codon is not subject to NMD despite being 7kb from the 3' poly(A) sequence. An RNA stability element (RSE) has been identified immediately downstream of gag in the RSV genome. It appears to determine the proper context for translation termination and protects the RNA from NMD. The viral stability element may prevent Up-frameshift 1 (Upf1) protein from interacting with the terminating ribosome and release factors to initiate NMD.
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http://dx.doi.org/10.1016/j.mib.2014.02.004 | DOI Listing |
Sci Total Environ
January 2025
Lab of Animal Ecology and Environmental Control, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, PR China; State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, PR China. Electronic address:
Organic fertilizers were produced through maggot-composting (MC) and natural composting (NC) using swine manure, and the migration, contamination, and health risks of heavy metals (Zn, Cu, Cd, Cr, Pb) were evaluated within a fertilizer - soil - ryegrass - Rex rabbit system. After 70 days of treatment, heavy metals were concentrated by 43.23 % to 100 % in MC and 52.
View Article and Find Full Text PDFJ Food Drug Anal
December 2024
Zhenjiang College, Zhenjiang, 212000, PR China.
Ascorbic acid (AA) is used as a food additive for its antibacterial and antioxidant properties. However, excessive intake of AA is harmful to humans. Therefore, the detection of Fe and AA is generally recognized to be meaningful.
View Article and Find Full Text PDFSci Rep
January 2025
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, China.
The main advantages of microneedles are precise drug delivery through human skin, minimal tissue damage and painlessness. We conducted structural analysis and skin puncture studies of hollow microneedles using ANSYS for three materials: Hafnium Dioxide (HfO), Polyglycolic acid (PGA) and Polylactic acid (PLA). Firstly, we selected three lengths, three tip diameters and three base diameters to conduct a L(3) orthogonal experiment.
View Article and Find Full Text PDFBiosens Bioelectron
December 2024
Computational Modeling and Nanoscale Processing Unit, Department of Food Process Engineering, National Institute of Food Technology Entrepreneurship and Management, Thanjavur (NIFTEM-T), Ministry of Food Processing Industries, Government of India, Thanjavur, 613005, Tamil Nadu, India. Electronic address:
A recently minted field of 3D-printed edible electronics (EEs) represents a cutting-edge convergence of edible electronic devices and 3D printing technology. This review presents a comprehensive view of this emerging discipline, which has gathered significant scientific attention for its potential to create a safe, environmentally friendly, economical, and naturally degraded inside the human body. EEs have the potential to be used as medical and health devices to monitor physiological conditions and possibly treat diseases.
View Article and Find Full Text PDFMikrochim Acta
January 2025
Shandong Provincial Key Laboratory of Animal Resistance Biology, Key Laboratory of Food Nutrition and Safety of Shandong, College of Life Science, Normal University, Shandong Normal University, Jinan, 250014, People's Republic of China.
A composite nanomaterial of Prussian blue@gold nanoparticles (PB@Au) with catalytic and photothermal properties was proposed, which combined with anti-matrix interference aptamers to achieve robust specificity and sensitivity in the detection of Salmonella typhimurium (S. typhimurium). The detection probe, PB@Au-Aptamer (PB@Au-Apt), was designed to exhibit high specificity for the target and catalyze the signal generation to produce a color change, thereby enabling rapid detection.
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