Ethanolic carbon-11 chemistry: the introduction of green radiochemistry.

Appl Radiat Isot

Division of Nuclear Medicine, Department of Radiology, The University of Michigan Medical School, Ann Arbor, MI, USA; The Interdepartmental Program in Medicinal Chemistry, The University of Michigan, Ann Arbor, MI, USA. Electronic address:

Published: July 2014

The principles of green chemistry have been applied to a radiochemistry setting. Eleven carbon-11 labeled radiopharmaceuticals have been prepared using ethanol as the only organic solvent throughout the entire manufacturing process. The removal of all other organic solvents from the process simplifies production and quality control (QC) testing, moving our PET Center towards the first example of a green radiochemistry laboratory. All radiopharmaceutical doses prepared are suitable for clinical use.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035440PMC
http://dx.doi.org/10.1016/j.apradiso.2014.01.033DOI Listing

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