From wavy hair to naked proteins: the role of transforming growth factor alpha in health and disease.

Semin Cell Dev Biol

Departments of Medicine and Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Veteran Affairs Medical Center, Nashville, TN 37232, USA. Electronic address:

Published: April 2014

Since its discovery in 1978 and cloning in 1984, transforming growth factor-alpha (TGF-α, TGFA) has been one of the most extensively studied EGF receptor (EGFR) ligands. In this review, we provide a historical perspective on TGFA-related studies, highlighting what we consider important advances related to its function in normal and disease states.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105142PMC
http://dx.doi.org/10.1016/j.semcdb.2014.03.003DOI Listing

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