AI Article Synopsis
- Two series of bis pyrazolones were synthesized, featuring either a 3-methyl or a 3-amino substituent, through cyclization reactions between hydrazides and esters/cyano esters in an ethanolic solution.
- The structures of the new compounds were validated using elemental analysis, IR, (1)H NMR, and mass spectrometry techniques.
- The series with the 3-amino substituent exhibited superior antibacterial and antifungal activity compared to the series with the 3-methyl substituent, with specific compounds showing greater antimicrobial effectiveness than others.
Article Abstract
Two series of bis pyrazolones (one with 3-methyl substituent and the other one with 3-amino substituent on the pyrazolone ring) were synthesized by the cyclization reaction between various hydrazides with esters/cyano esters in ethanolic medium. Structures of newly synthesized compounds were confirmed by elemental analysis, IR, (1)H NMR and mass spectral data. These compounds were screened for antibacterial and antifungal activities. The compounds of series 3 with amino substituent demonstrated better activity than the compounds of series 2 with methyl substituent on the pyrazolone ring. Compounds "e, f, c and d" showed higher antimicrobial activity than the compounds "b and a". The antimicrobial potentials of the synthesized compounds were compared with that of standards.
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| http://dx.doi.org/10.1016/j.pharma.2013.11.005 | DOI Listing |
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