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Efficacy and safety of upadacitinib versus dupilumab in adults and adolescents with moderate-to-severe atopic dermatitis: week 16 results of an open-label randomized efficacy assessor-blinded head-to-head phase IIIb/IV study (Level Up).
Br J Dermatol
December 2024
Department of Dermatology and Venereology, Medical Center, University of Freiburg, Freiburg, Germany.
Article Synopsis
- * The study compared the effectiveness and safety of upadacitinib (UPA) and dupilumab (DUPI) in adolescents and adults with moderate-to-severe AD over 16 weeks, with UPA showing better results in reducing skin severity and itching.
- * UPA was found to be significantly more effective than DUPI in achieving the treatment goals, with no new safety concerns reported during the study.
Evaluation of the Efficacy of an Ecobiological Dermo-Cosmetic Product to Help Manage and Prevent Relapses of Eyelid Atopic Dermatitis.
Clin Cosmet Investig Dermatol
March 2023
NAOS Group, Research and Development Department, Aix-en-Provence, 13290, France.
Purpose: Atopic dermatitis (AD) is a chronic relapsing, inflammatory disease which causes eczematous lesions. Itching and symptoms visibility can have a significant impact on quality of life. This is the case when eyelids are affected.
View Article and Find Full Text PDFAnti-Mi-2 and Anti-TIF1-γ Double-Positive Juvenile Dermatomyositis Treated under Diagnosis of Chronic Eczema: A Case Report.
Tohoku J Exp Med
April 2022
Department of Rheumatology, Fukushima Medical University School of Medicine.
Myositis-specific autoantibodies are relevant factors that define the disease phenotype of dermatomyositis (DM). Anti-Mi-2 antibody-positive DM patients may present with the typical skin lesions and prominent myositis. On the other hand, adult DM patients with anti-TIF-γ antibody seem to be associated with internal malignancy.
View Article and Find Full Text PDFAllergic Contact Dermatitis by Anatomical Regions: Diagnostic Clues.
Actas Dermosifiliogr (Engl Ed)
April 2019
Servicio de Dermatología, Hospital de la Sant Creu i Sant Pau, Barcelona, España.
Allergic contact dermatitis (ACD) is a common disease in daily clinical practice, and its prevalence has increased in recent years. It is characterized clinically by varying degrees of erythema, vesiculation, flaking, and lichenification, though these signs can also be present in other eczematous diseases. Patch testing is the main diagnostic tool to confirm ACD, but its accurate interpretation requires correct correlation with the medical history (details of exposure) and physical examination.
View Article and Find Full Text PDFChronic actinic dermatitis.
Dermatol Clin
July 2014
Department of Dermatology, Henry Ford Hospital, 3031 West Grand Boulevard, Suite 800, Detroit, MI 48202, USA.
Chronic actinic dermatitis (CAD) is an immunologically mediated photodermatosis characterized by pruritic eczematous and lichenified plaques located predominantly on sun-exposed areas with notable sparing of eyelids, skin folds, and postauricular skin. CAD is thought to be due to secondary photosensitization of an endogenous antigen in the skin. Management of CAD should include strict photoprotection and topical agents, including corticosteroids and calcineurin inhibitors.
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